Talk:Influenza

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Featured article Influenza is a featured article; it (or a previous version of it) has been identified as one of the best articles produced by the Wikipedia community. Even so, if you can update or improve it, please do so.
Main Page trophy This article appeared on Wikipedia's Main Page as Today's featured article on January 1, 2007.
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October 20, 2006 Good article nominee Listed
October 23, 2006 Peer review Reviewed
November 2, 2006 Featured article candidate Promoted
Current status: Featured article


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Why is the section on Neuraminidase inhibitors so bad?[edit]

It didn't tell me what they are. I would have liked to see, "neuraminidase inhibitors act on the protein X-and-so that buds the newly-formed virus off the host cell...." The sort of thing that would tell me what a neura inhibitor actually is.

Instead it's all about why the author thinks they are bad. It sounds biased to me, and I'm a random user with no prior knowledge. The same sentence "the benefits of neuraminidase inhibitors in those who are otherwise healthy..." appears twice in this article, a third time on the page for neuraminidase inhibitors. I think someone is spouting their personal belief. -- Unsigned

It appears that in 2013, a user threw out the old NAI section and inserted a rather opinionated conclusion. Though I'm not sure that it would classify as personal as I believe it reflected recent findings of the time; and the conclusions of one center specifically. Perhaps you could salvage some of the introduction from before the rewrite. Although I think one should avoid repeating the general descriptions found on the dedicated Neuraminidase inhibitor page. C. lorenz (talk) 19:13, 8 September 2017 (UTC)
About the strongly-voiced conclusion echoed throughout the page, I would say it's a somewhat controversial point to this day. Perhaps the section should reflect this. Roche indeed withheld data and independent analyses did not find the drug to be as effective as tentatively advertised. Some flack is well deserved for this reason. However, even those studies indicated effects other than shortened disease. In addition to their trials, there is extensive treatment data since. Reviews not restricted to the Roche trials indeed indicate other significant effects, e.g. prevention of clinical infections and reduction in hospital admission. WHO changed their recommendation this summer about stockpiling antivirals as essential for influenza pandemics, though still recommending it for treating severe cases. This was likely inspired by statements and reviews originating from the BMC, which in turn appear largely based on the Roche trials. More recently, the ECDC released a broader literature review. Therein, it is indeed concluded that there is evidence for drug effectiveness beyond shortened disease. Along with support for the broad use as pandemic treatment and prevention. I would say that these strong statements on the page do not appear to be true given present understanding. C. lorenz (talk) 19:13, 8 September 2017 (UTC)

There are now 18 H and 11 N subtypes, not 16 or 9 anymore[edit]

Please change: "There are 16 H and 9 N subtypes known," to "There are 18 H and 11 N subtypes known"--new research is responsible for this. These are the citations:

[1] [2]

References

  1. ^ Tong S, Li Y, Rivailler P, Conrardy C, Castillo DA, Chen LM, et al. A distinct lineage of influenza A virus from bats. Proceedings of the National Academy of Sciences of the United States of America. 2012;109(11):4269–74. doi: 10.1073/pnas.1116200109 pmid:22371588; PubMed Central PMCID: PMC3306675.
  2. ^ Tong S, Zhu X, Li Y, Shi M, Zhang J, Bourgeois M, et al. New world bats harbor diverse influenza A viruses. PLoS pathogens. 2013;9(10):e1003657. doi: 10.1371/journal.ppat.1003657 pmid:24130481; PubMed Central PMCID: PMC3794996.

External links modified[edit]

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External links modified[edit]

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Lancet seminar[edit]

doi:10.1016/S0140-6736(17)30129-0 JFW | T@lk 16:42, 14 August 2017 (UTC)