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6 are known, what percentages are in kava. What are their names, what do the molecules look like? The article doesn't say... heres 3 of the kavalactones. Needs expansion. --x1987x(talk) 04:40, 16 January 2007 (UTC)

Probably "(+)-methysticin, (+)-dihydromethysticin, (+)-kavain, (+)-dihydrokavain, yangonin, and desmethoxyyangonin" ( It'd be nice if someone knew what they did. On the main page desmethoxyyangonin is identified as a reversible mao-b inhibitor. I'd like to know what the other 5 do. —Preceding unsigned comment added by (talk) 08:01, 10 February 2008 (UTC)

Last three chemical structures[edit]

Looking at the last 3 structures of kavalactones, by their substitution there seems to be no difference between them...could there be a mistake here, or is there some sort of sterics thing I'm missing here? 17:14, 15 August 2007 (UTC)

Double bonds (in the rings) are in different places --x1987x(talk) 01:42, 27 October 2008 (UTC)

Removed content[edit]

Much of the content [that was] in this article needs to be reincorporated into the articles about the specific kavalactones referenced.   — C M B J   03:03, 5 September 2009 (UTC)

  1. ^ Hu, A; et al. (2005). "Determination of six kavalactones in dietary supplements and selected functional foods containing Piper methysticum by isocratic liquid chromatography with internal standard". J AOAC Int. 88 (1): 16–25. PMID 15759721. 
  2. ^ Thompson, R; et al. (2004). "Enhanced cognitive performance and cheerful mood by standardized extracts of Piper methysticum (Kava-kava)". Hum Psychopharmacol. 19 (4): 243–250. doi:10.1002/hup.581. PMID 15181652. 
  3. ^ Cairney, S; et al. (2002). "The neurobehavioural effects of kava". Aust N Z J Psychiatry 36 (5): 657–652. doi:10.1046/j.1440-1614.2002.01027.x. PMID 12225450. 
  4. ^ Hunter, A (2006). "Kava (Piper methysticum) back in circulation". Australian Centre for Complementary Medicine 25 (7): 529. 
  5. ^ Cairney, S; et al. (2003). "Saccade and cognitive function in chronic kava users". Neuropsychopharmacology 28 (2): 389–396. doi:10.1038/sj.npp.1300052. PMID 12589393. 
  6. ^ Uebelhack R, Franke L, Schewe HJ (1998): “Inhibition of platelet MAO-B by kava pyrone-enriched extract from kava-kava.” Pharmacopsychiatry 31(5):187-92. PMID 9832350
  7. ^ Baum SS, Hill R, Rommelspacher H (1998): “Effect of kava extract and individual kavapyrones on neurotransmitter levels in the nucleus accumbens of rats.” Prog Neuropsychopharmacol Biol Psychiatry 22(7):1105-20. PMID 9829291
  8. ^ Seitz U, Schule A, Gleitz J (1997): "[3H]-monoamine uptake inhibition properties of kava pyrones." Planta Med. 63(6):548-9. PMID 9434608
  9. ^ Nerurkar, PV; et al. (2004). "In vitro toxicity of kava alkaloid, pipermethystine, in HepG2 cells compared to kavalactones". Toxicological Sciences 79 (1): 106–111. doi:10.1093/toxsci/kfh067. PMID 14737001. 
  10. ^ Singh, Yadhu; Ashwini Devkota (2003 June). "Aqueous kava extracts do not affect liver function tests in rats." (PDF). Planta Medica 69 (6): 496–499. PMID 12865965. Retrieved 2009-09-04.  Cite uses deprecated parameter |coauthors= (help); Check date values in: |date= (help)
  11. ^ Matthias, A.; J. T. Blanchfield, K. G. Penman, K. M. Bone, I. Toth, R. P. Lehmann (2007 June). "Permeability studies of Kavalactones using a Caco-2 cell monolayer model". Journal of Clinical Pharmacy and Therapeutics 32 (3): 233–239. PMID 17489874 doi:10.1111/j.1365-2710.2007.00810.x.  Cite uses deprecated parameter |coauthors= (help); Check date values in: |date= (help);