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This article is a little messy and could do with some rearranging. The medicinal uses part needs some subsections, and some thought might be given to partial merge with the medical research section. — Preceding unsigned comment added by Testem (talk • contribs) 10:28, 15 January 2014
Ketamine's antidepressant action possibly caused by AMPAR inhibition rather than NMDAR inhibition.
Hi! After seeing it on the NIH Director's blog, I added some information about indications that ketamine's fast-acting antidepressant effects may be caused by one of its metabolites, which doesn't have the same potential for abuse. (Study published in Nature.) It's been integrated into the article for hydroxynorketamine, the metabolite in question. The revert message says to look at WP:MEDRS; this is recently published, so it doesn't appear in any reviews yet, but it seems important enough to include at least some note of it. ("If conclusions are worth mentioning [...] they should be described appropriately as from a single study".) Am I missing something here? Thanks! grendel|khan 00:59, 15 May 2016 (UTC)
Thanks for opening this, I was about to. User:Doc James and User:Seppi333, are you good with the current version here? I am somewhat surprised at myself for arguing to keep this content based on a primary source, but seeing how we do use primaries for purely PK stuff (seppi's objection here was dead on) I don't see a reason to exclude this now. And it is a major upheaval in the understanding of how this drug works, i think.... If you all say yes wait for a review I can only bow to that, of course. Jytdog (talk) 01:23, 15 May 2016 (UTC)
The current version seems fine; the sources for the current statement should only need to satisfy WP:SCIRS, which they do. Seppi333 (Insert 2¢) 01:30, 15 May 2016 (UTC)
Maybe I'm missing the point here, but the whole reason this is an interesting finding is that HNK doesn't have the same side effects and abuse potential, right? Even if the main question here--HNK has ketamine's antidepressant effects--is still under investigation, that's valuable context, right? grendel|khan 00:33, 22 May 2016 (UTC)
It is interesting for a lot of reasons. But we are limited by what we can say based on a given source by the sourcing guideline. To make claims in content about health we need a review in the biomedical literature. I have no doubt one will be forthcoming soon that talks about this. It just a matter of waiting a bit. Jytdog (talk) 01:13, 22 May 2016 (UTC)
In the Anaesthesia section the statement "It is sometimes possible to perform ketamine anesthesia without protective measures to the airways." is not referenced. There does not appear to be a readily apparent source for this statement. This is often the case in animal anaesthesia where Ketamine or a combination with it and another anaesthetic is used without airway support. However in human anaesthesia, it does not appear to be used without airway support due to its pro-salivary properties: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25886322/
In the Vetinary Medicine section, the statement "Ketamine is used to manage pain among large animals, though it has less effect on bovines." is not referenced. There does not appear to be any scientific articles that make note of a lesser effect on bovines relative to other animals. Given the complexity of inter-species dose scaling, I wonder if this statement is useful. — Preceding unsigned comment added by Yossarian54 (talk • contribs) 03:52, 1 February 2017 (UTC)
Over the last 15 years, ketamine has been found to be very effective as an antidepressant when administered intravenously in sub-anaesthetic doses. Over 100 independent clinical trials at leading institutions such as The National Institute of Mental Health, The Cleveland Clinic, Mt. Sinai Hospital, Yale University, Stanford University, UCLA, USC, and NYU, have been conducted. Average response rate to Ketamine Infusion Therapy among participants across all the studies is about 70%. In the last 5 years, there has been a significant increase in the number of ketamine clinics in the United States offering the treatment to the general public. 
However advancements over the last 15 years show that ketamine has been found to be very effective as an antidepressant when administered intravenously in sub-anaesthetic doses. Over 100 independent clinical trials at leading institutions such as The National Institute of Mental Health, The Cleveland Clinic, Mt. Sinai Hospital, Yale University, Stanford University, UCLA, USC, and NYU, have been conducted. Average response rate to Ketamine Infusion Therapy among participants across all the studies is about 70%. In the last 5 years, there has been a significant increase in the number of ketamine clinics in the United States offering the treatment to the general public.
The section of the article where you put this content is "medical use". Content that goes into this section needs to describe medical use, and be sourced per WP:MEDRS, which briefly means a fairly recent literature review published in the biomedical literature, or a statement by a major medical medical or scientific body. The content in that section already describes medical use and the evidence for it, and is sourced to a fairly recent review.
The first source is an interview in NY Magazine and is not MEDRS. The second source is a news piece by the NIH, which is also not a MEDRS source.
The content is also very promotional, and obviously so, and really importantly, not supported by either source.Jytdog (talk) 00:14, 25 March 2017 (UTC)