Talk:Leonard Hayflick

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Review comments[edit]

Some suggestions for improvement as the article is expanded:

  • Some disorganisation and repetition between sections needs attention
  • Template:Infobox Scientist should be added
  • Photograph should be added from a source with a free license
  • Needs some copy editing and wikification
  • Some references present, but most material is unsourced
  • External link present which could be used to expand article

Espresso Addict 01:36, 13 July 2007 (UTC)

NPOV?[edit]

This article seems to read almost like a fan site. There are virtually no references given for the claims made about Hayflick's accomplishments. It is in dire need of an expert's attention. 2tuntony (talk) 20:12, 24 August 2010 (UTC)

= August 25, 2010 ====== COMMENT ==========[edit]

Weismann-Swim-Hayflick Limit The antiquated idea that lifespan might be determined by the limited capacity of somatic cells to divide was originated by the famous German biologist August Weismann in 1892 (1). Mechnikov, who coined the term “gerontology,” discussed Weismann’s theory of cell division limit in his book “Essais optimistes” published in 1907 (2). In the 1950s the first convincing experimental evidence that animal cells in culture cannot be propagated indefinitely was presented by Swim, Parker, and Haff from Western Reserve University School of Medicine (3 – 5), and their results were reproduced by Hayflick and Moorhead in 1961 (6). The popular press has persisted in using the term “The Hayflick Limit” to promote the scientifically naïve idea that the human lifespan is determined by a limited number of cell divisions, although the relevance of finite divisions by fibroblasts in culture to lifespan in an organism, e.g. a person, is highly questionable (7, 8, 9). The observation that many types of cells derived from normal tissue have a finite capacity to divide in culture might be more accurately termed the Weismann-Swim-Hayflick Limit (10). 1. Weismann, A. (1892). Uber Leben und Tod. Verlag von Gustav Fisher, Jena. 2. Mechnikov, I.I. (1907). Essais optimistes. Paris, 438 p. Author: Mechnikov, I. I. (Ilíà Ilich), 1845-1916 Subject: Longévité Publisher: Paris: A. Maloine Language: French; Russian Call number: b1650679 Digitizing sponsor: University of Ottawa Written in French. Titre original: Etiudy optimizma. 3. Haff, R.F. and Swim, H.E. (1956). Serial propagation of 3 strains of rabbit fibroblasts; their susceptibility to infection with Vaccinia virus. Proc.Soc.Exp.Biol.Med., 93, 200-204. 4. Swim, H.E. and Parker, R.F. (1957). Culture characteristics of human fibroblasts propagated serially. Am.J.Hygiene, 66, 235-243. 5. Swim, H.E. (1959). Microbiological aspects of tissue culture. Ann.Rev.Microbiol. 13, 141-176. 6. Hayflick, L., Moorhead, P.S. The serial cultivation of human diploid cell strains. Exp Cell Res. 1961;25:585-621. 7. Rubin H. The disparity between human cell senescence in vitro and lifelong replication in vivo. Nat Biotechnol. 2002 Jul;20(7):675-81. Review. PMID: 12089551 8. Macieira-Coelho A. The implications of the 'hayflick limit' for aging of the organism have been misunderstood by many gerontologists. Gerontology. 1995;41(2):94-7. Review. 1995;41(4):241. PMID: 7744273 9. de Magalhães JP. From cells to ageing: a review of models and mechanisms of cellular senescence and their impact on human ageing. Exp Cell Res. 2004 Oct 15;300(1):1-10. Review.PMID: 15383309 10. Gavrilov, L.A. and Gavrilova, N.S. (1991). The Biology of Life Span: a Quantitative Approach. Harwood Academic Publishers GMBH, Chur, etc. ISBN: 3-7186-4983-7. MoJohn47 (talk) 17:07, 25 August 2010 (UTC)MoJohn


Greetings,
I support comments made by MoJohn47 and suggest that they be added to the article. I also agree with 2tuntony that this article is in dire need of an expert's attention. Here are some relevant excerpts from a scientific book, which may help to those who will do such rewriting:
http://longevity-science.org/pdf/Biology-of-Lifespan-5.6.pdf
Good luck!
Gavrilov (talk) 23:56, 20 August 2011 (UTC)