Talk:Medium spiny neuron

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Corpus striatum of the basal ganglia?[edit]

I think there's an issue with the location of "75% of the neurons within the corpus striatum of the basal ganglia". When I click on the link to corpus striatum, it doesn't really give me any location, other than to say it's another name for the basal ganglia. Maybe we can get a better description of these neurons, or a better description of the corpus striatum per this article. Rhetth 20:38, 15 October 2007 (UTC)


Does anyone have a reference for the assertion of "90% of the neurons within the corpus striatum of the basal ganglia"? I've been trying to check this up for a couple of days. The numbers differ for different species - over 95% in rats and mice, and 75-80% in primates (e.g. Chapter 1, of Tepper J.M., Abercrombie E.D. and Bolam J.P. (eds), GABA and the Basal Ganglia: From Molecules to Systems, Progress in Brain Research Vol 160, Elsevier B.V., 2007. I've also seen "These GABAergic (GABA is γ-aminobutyric acid) cells are the most populous neuronal cell type of the striatum (90–95% in rats and over 85% in humans)" in Kelly C.M., Dunnett S.B. and Rosser A.E., Medium spiny neurons for transplantation in Huntington’s disease, Biochem. Soc. Trans. (2009) 37, 323–328; doi:10.1042/BST0370323. But nowhere have I seen a value of 90% or over for humans.

Perhaps it would be an idea to split off the values for different species and give citations for each?

I'm also going to make this comment on the Talk: Striatum page, where the figure is given as 96% - apologies for the multiple post, but these numbers really need the attention of an expert in the field - which I am not.

Baratron (talk) 06:16, 30 November 2010 (UTC)