|This is the talk page for discussing improvements to the Methamphetamine article.|
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|Text from this version of Methamphetamine was copied or moved into Amphetamine: History, Society, and Culture with this edit on September 24, 2013. The former page's history now serves to provide attribution for that content in the latter page, and it must not be deleted so long as the latter page exists.|
|Text from this version of Methamphetamine was copied or moved into Amphetamine: History, Society, and Culture with this edit on December 31, 2013. The former page's history now serves to provide attribution for that content in the latter page, and it must not be deleted so long as the latter page exists.|
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Amendment to the first sentence
Hi, I think the first sentence should instead read like: "Methamphetamine[note 1] (pronunciation: //; contracted from N-methyl-alpha-methylphenethylamine) is a neurotoxin and potent psychostimulant of the phenethylamine and amphetamine classes, that is used medically, in some countries, to treat resistant cases of attention deficit hyperactivity disorder (ADHD) and obesity, but is better known for its role as an infamous drug of abuse."
Note: I have ignored much of the formatting in this sentence, the bolding and hyperlinking of the words and letters I think is fine the way it is.
Now my reasoning for this suggested change is that most people don't know it's used to treat ADHD or obesity, even there it's only used in some countries (mostly North American countries) and even then only in resistant cases, hence it might be more helpful to mention this and the fact it is well-known drug of abuse. I would just edit it myself, but I felt as this is a good article a consensus should be reached on something as important as the first sentence. Thoughts and opinions will be welcome by anyone. Even people I tend to ruffle the feathers of as I do still value their opinions as Wikipedia is still a democracy. Brenton (contribs · email · talk · uploads) 14:29, 20 July 2014 (UTC)
I like how it says that meethamphetamine is much more toxic than ritalin and amphetamine. This makes no sense. At low doses toxicity would be absolutely the same. I am not even saying that it compares meth additcs to schoolers on ritaline by 18mg. Higher toxicity is achievable only at large doses due to more powerful output capabilities of meth. Extreemator (talk) 06:45, 31 July 2014 (UTC)
- The article states that meth is neurotoxic even at low doses in humans – and amphetamine and methylphenidate are not – because that's what the citations say. The article compares the neuroplastic effect of high dose meth to those of low dose amph because that's as much as could be said from neuroimaging reviews wrt those drugs in humans.
I'd suggest reading the sources if you want an explanation about a statement. Seppi333 (Insert 2¢ | Maintained) 00:06, 2 August 2014 (UTC)
Levmetamfetamine as a USAN
I'm fairly certain that levomethamphetamine doesn't have a USAN, since it has never been a pharmaceutical drug in the United States. I've read elsewhere that manufacturers (e.g., Vicks) use the INN on their packaging primarily to avoid the stigma associated with the term "methamphetamine". In any event, I'd normally just remove a clause I find dubious, but I figured I'd ask first: do you have a ref for the levmetamfetamine USAN? Nevermind, it's apparently in the very same ref I used to cite the INN... I'm clearly very perceptive. >.> Seppi333 (Insert 2¢ | Maintained) 23:45, 6 October 2014 (UTC)
Clarity on freebase vs salts
It's obvious to me why the melting point is listed as 3*C but that's likely to seem very weird for the majority of the population. Should it be made clearer that many of the chemical properties are referring to the freebase oil and not the more commonly seen hydrochloride salt?
Semi-protected edit request on 27 December 2014
|This edit request has been answered. Set the
"Unlike amphetamine, methamphetamine is directly neurotoxic to dopamine neurons." Source 39 is bogus, the authors do not cite any research to support this statement, it seems to be no more than an opinion. "Methamphetamine also inhibits VMAT1, has agonist activity at all alpha-2 adrenergic receptor and sigma receptor subtypes, and is directly toxic to dopamine neurons in humans, whereas there is no evidence of acute amphetamine toxicity in humans." None of the cited sources support the statement that there is no amphetamine toxicity in humans. That statement should be removed or supported by valid sources. 220.127.116.11 (talk) 00:47, 27 December 2014 (UTC)
- See WP:MEDRS for what constitutes a valid medical source. Seppi333 (Insert 2¢ | Maintained) 01:00, 27 December 2014 (UTC)
Off-label use of prescription methamphetamine?
Is there any off-label medical uses for prescription methamphetamine other than ADHD and obesity? Probably narcolepsy, idiopathic hypersomnia and depression but without sources this is just a guess. Clr324 (say hi) 08:24, 19 February 2015 (UTC)
- I imagine all of those are, but I doubt I can find a source that says that. Seppi333 (Insert 2¢ | Maintained) 01:55, 20 February 2015 (UTC)
@Boghog: Hey, hope it's not too muxh to ask, but can you draw a new structure diagram for this article as well when you get a chance? I'd like to keep the Dbox images consistent across articles. Seppi333 (Insert 2¢ | Maintained) 02:51, 4 April 2015 (UTC)
- No problem. I have updated the structure so that it is consistent with the one used in amphetamine. Boghog (talk) 09:28, 4 April 2015 (UTC)
Recreationally, methamphetamine is used to increase sexual desire, lift the mood, and increase energy, allowing some users to engage in sexual activity continuously for several days straight.
- Done although the entire recreational use section needs expansion. Sizeofint (talk) 16:21, 15 April 2015 (UTC)
- The current ref for this sentence in the lead par is San Francisco Meth Zombies (TV documentary). National Geographic Channel. August 2013. ASIN B00EHAOBAO. Is this is an adequate source?? I know the sentence is prefixed with "Recreationally", but the inference is that meth enables continuous bonking for several days straight. So first qn is: is it true? 2nd qn: my body can be aroused that long much without any drugs (it can get to the state that the more we have sex, the more we want to have sex; my girlfriend's tendency to orgasm remains roughly constant, my frequency of ejaculation reduces with time and my refractory period grows), but we would not be capable of staying awake that long or being so obsessed for so long without drugs - this suggests to me that the most pertinent factor is not so much that meth enables extended sexual performance, but that it enables extreme wakefulness and obsession; is clarification along these lines appropriate? — Preceding unsigned comment added by 18.104.22.168 (talk) 12:51, 10 May 2015 (UTC)
- Yes, this should be clarified. This section needs additional information and sources so everything is not based off a National Geographic documentary. Sizeofint (talk) 21:22, 10 May 2015 (UTC)
LOL, who edited that one? Amphetamine of even garden variety is technically necrotic to neuron integrity DEPENDENT UPON MULTI-FACTORIAL CRITERIA - the statement "UNLIKE AMPHETAMINE..." simply stupidly fails to delve into these, unhelpfully and the simplism is brutal. As if your kid's Ritalin or Adderall was a magically different compound than Desoxyn... Someone state the facts more subtly and wisely here, rephrase things... Makes Wikipedia look retarded. Genetic polymorphisms of individuals and a million other factors determine whether amphetamine shall prove neurologically damaging, but the reality of its capacity above all these contingent factors, to obliterate Homo Sapiens axon-dendrite-ETC. connections necessary for cephalic functionality, is just a brute factum. — Preceding unsigned comment added by 2602:304:B34B:A940:F051:AB0F:3A76:DE48 (talk) 04:34, 19 June 2015 (UTC)
- The reference for that statement is reliable but is somewhat on the old side. If you have a newer WP:MEDRS compliant source feel free to provide it and we can update this section. Sizeofint (talk) 05:11, 19 June 2015 (UTC)
- Lol. There's a link to the sections in the body right after that statement... the superscripted [i] and [iii], which explains one significant pharmacodynamic and associated toxicodynamic difference that has been identified between methamphetamine and amphetamine. Did you bother clicking that link before ranting here? A single methyl group is the difference between phenethylamine and amphetamine as well, so maybe the brain produces its own necrosis-inducing neurotoxins? Seppi333 (Insert 2¢) 07:25, 19 June 2015 (UTC)
Reviews to add (at some point)...
-  - includes coverage of human low-dose methamphetamine-induced neurotoxicity
-  - 2nd human neurotoxicity review
- Completely rewrite Methamphetamine#Comparison to amphetamine pharmacodynamics based upon their distinct intracellular signaling dynamics.
- Glial review
- 2014 review on stimulant sigma-1 receptor ligand neurotoxicity
- Need to spend more time looking for a primary source or review covering nNOS stimulation, peroxynitrite production, or reactive nitrogen species-mechanisms associated with amph in humans --- might not matter