Talk:Multiple myeloma

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WikiProject Medicine / Hematology-oncology (Rated B-class, Mid-importance)
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Reviews[edit]

Numerous translational reviews in Blood this week: http://bloodjournal.org/content/125/20 - 15 May 2015‎

Refractory and relapsed disease[edit]

Network meta-analysis doi:10.1182/bloodadvances.2016003905 JFW | T@lk 20:28, 13 March 2017 (UTC)

Relapse[edit]

Proposed edit: Following the sentence "Bortezomib is a proteasome inhibitor," add, "Identifying the levels of specific proteins may help doctors identify whether a patient will benefit from a proteasome inhibitor." Citation: doi:10.18632/oncoscience.356

I'd like to open this to discussion because the citation is primary research, so not ideal. However, the first sentence does not give readers any context as the significance of being a proteasome inhibitor or how physicians use that information. The purpose of this edit would be to help fill that gap. Thoughts? Cglife.trummler (talk) 22:43, 14 November 2017 (UTC)

I'm sure there are better sources that are more compliant with WP:MEDRS. I find a fair number when searching Pubmed with "proteasome inhibitors" as MAJR term. JFW | T@lk 23:01, 14 November 2017 (UTC)
No. We call this WP:REFSPAM. Please stop doing this. Thanks. Jytdog (talk) 06:13, 15 November 2017 (UTC)

Updating and expanding prognosis info[edit]

Two points:

1. The Prognosis section states "Overall the 5-year survival rate is around 35%". The source for this (63) states "Archived from the original on 11 January 2013." However, following the source link given leads to an article that notes at the top it has been updated on Jan 11, 2018. In that article, under the heading Prognosis it says "The 5-year relative survival rate is 46.6%." I am not expert enough to know if "overall" and "relative" have different meanings in this context, but it appears to me as if the survival rate has improved since the original source was written. Should this be updated?

2. The same source (https://emedicine.medscape.com/article/204369-overview#showall) also gives information on the difference in prognosis due to type of treatment:

The prognosis by treatment is as follows:

• Conventional therapy: Overall survival is approximately 3 years, and event-free survival is less than 2 years.

• High-dose chemotherapy with stem-cell transplantation: The overall survival rate is greater than 50% at 5 years.

This might be good information to include.

Grindle2095 (talk) 13:41, 27 January 2018 (UTC)

Medscape isn't an ideal source. I agree that there must be a more recent MEDRS-compatible source present somewhere. JFW | T@lk 22:49, 27 January 2018 (UTC)
How about SEER Cancer Statistics Review? (https://seer.cancer.gov/csr/1975_2014/) (Based on data up to 2014) You can see the relevant tables here: https://seer.cancer.gov/csr/1975_2014/browse_csr.php?sectionSEL=18&pageSEL=sect_18_table.08.html Grindle2095 (talk) 06:58, 28 January 2018 (UTC)