Talk:Na-K-Cl cotransporter

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Gene names[edit]

I just changed the names on the gene boxes (Slc12a1 was labelled "...member 2" and vice versa) but the links aren't right now for some of them, and 2 is above 1 on the page, someone with the time should really change it round... — Preceding unsigned comment added by Maddo16 (talkcontribs) 18:02, 11 August 2013 (UTC)

Fixed. Gon-no-suke (talk) 04:13, 9 May 2016 (UTC)

Sodium Concentration[edit]

the fluid in the lumen at the thick ascending limb is actually dilute in comparison to the rest of the Loop of Henle - so the statement regarding the sodium concentration at this portion of the tubule seems wrong.

Active transport[edit]

is this an active transport process?

Depends what you mean by an active transport process. No ATP is used in the exchange, but it depends on an ion gradient being there in the first place, which is energy dependent. "semi active" might be a better term.
Processes that use ATP directly are called primary active transport. Those that use it indirectly, usually referring to their use of the ATP-dependent sodium electrochemical gradient, are called secondary active transport. So NKCC transporters use secondary active transport. --David Iberri (talk) 13:23, 13 October 2008 (UTC)


Also, can someone clarify which direction each ion is moving? (talk) 19:49, 4 April 2008 (UTC)

Most (if not all) NKCC proteins transport solutes into the cell. --David Iberri (talk) 13:23, 13 October 2008 (UTC)

Na and Cl ions are transported passively (facillated diffussion) while K is transported via secondary active transport. Is this true? —Preceding unsigned comment added by (talk) 15:05, 27 August 2010 (UTC)