|WikiProject Chemicals||(Rated Start-class, Mid-importance)|
|WikiProject Pharmacology||(Rated Start-class, High-importance)|
|WikiProject Medicine||(Rated Start-class, Mid-importance)|
|This article was nominated for merging with Niacin on 2015-05-15. The result of the discussion was not to merge.|
|This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Assigned student editor(s): JacobShalk. Assigned peer reviews: Lovinne.|
- 1 Nicotinic acid vs. nicotinamide
- 2 Nicotinamide
- 3 Inositol Nicotinate
- 4 confusion with "Nicotine"?
- 5 The Chinese translations of the chemical are based on the following....
- 6 Merger proposal
- 7 Move to Niacinamide instead of merge with Niacin
- 8 Biochemistry?
- 9 Assessment comment
- 10 Why was reference to use for cancer and skin cancer removed?
- 11 Biochemistry and Structure
Nicotinic acid vs. nicotinamide
The beginning section of this article seems confused. Nicotinic acid is not converted to nicotinamide before being converted to NAD. It's converted after. Nicontinic acid first forms NaMN -> NaAD -> NAD then is deconverted back to nicotinamide from NAD like everything else that forms NAD. But saying it's converted to nicotinamide in vivo makes it seem like nicotinic acid is just a bad precursor for nicotinamide, when in fact the only common pathway happens after the conversion to NAD, which isn't an important fact. http://jpet.aspetjournals.org/content/324/3/883/F3.large.jpg — Preceding unsigned comment added by 188.8.131.52 (talk) 09:52, 3 December 2014 (UTC)
It is??? I thought it was a B vitamin. -- Marj Tiefert, Saturday, April 6, 2002
I know that there's a diffence between nicotinimide and nicotinic acid but what about Inositol Nicotinate? I noticed that GNC and some other retailers are selling Inositol Nicotinate labeled as niacin. What's the difference? —Preceding unsigned comment added by Interestedperson (talk • contribs) 15:58, 3 July 2007
confusion with "Nicotine"?
I think there are grounds for concern that many persons are misled by what appears to be old-fashioned nomenclature, i.e. the appearance of derivatives of the root word "nicotin-" in numerous names of substances related to Vitamin B3 or Niacin. The history of this confusion should be researched and cited in this article. It can have the effect of legitimizing nicotine or making some persons believe nicotine is a vitamin or otherwise related to the medical uses of niacinamide. —Preceding unsigned comment added by Tokerdesigner (talk • contribs) 19:28, 9 April 2008 (UTC)
The Chinese translations of the chemical are based on the following....
Move to Niacinamide instead of merge with Niacin
In view of the approximate consensus reached in the above discussion of a proposed merger with Niacin, I propose that instead this article be moved to Niacinamide. The parallel names, Niacin and Niacinamide, would better indicate the chemical similarity and relation between the two substances than the present names Niacin and Nicotinamide, while their different pharmacological properties can be better conveyed by keeping the two articles separate than by merging them, as I had formerly proposed.CharlesHBennett (talk) 20:13, 5 July 2015 (UTC)
I know biology - I don't know pathology etc.
Can anybody create a section on how and where this stuff participates rather than just having a nobody-except-medics-knows habraquadabrah with references to diseases: "it is used in treating schmatibulosis quadrabupulos", I don't know. There is a holystic approach, the main systems, blah-blah-blah. I came here and I ONLY LEARNT that this chemical is a vitamin, within group B, all right, but I cannot possibly get anything else from this article as it is now. Nothing. Nada. Zero. 184.108.40.206 (talk), Josh — Preceding undated comment added 17:37, 21 July 2015 (UTC)
The comment(s) below were originally left at several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section., and are posted here for posterity. Following
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More references are needed for the "Use in medicine" section. Most of the content in the section consists of unrelated single sentences that do not provide enough context to be meaningful; thus, expansion is needed.
As others have questioned in this talk page, there is confusion with prefix "nicotin-" that warrants an explanation in the article. Information about the naming of this compound can be found in Niacin#History.--Tea with toast (talk) 03:04, 6 September 2009 (UTC)
Question: are not the root word "nicotin-" and its variants old-fashioned as alternatives to "niacin", "niacinamide" etc.? Is there not a danger that some readers will be confused and think that the retention of this improper usage implies a medical approval of nicotine, or a relationship between nicotine and Vitamin B3?Tokerdesigner (talk) 19:33, 9 April 2008 (UTC)
Last edited at 03:04, 6 September 2009 (UTC). Substituted at 01:14, 30 April 2016 (UTC)
Why was reference to use for cancer and skin cancer removed?
Why was reference to use for cancer and skin cancer removed in edit made on 05:09, 30 December 2016 by Doc James?
p.s. not sure if this is the appropriate way to discuss a specific article edit or if it should be done elsewhere — Preceding unsigned comment added by 2605:E000:1C0A:C054:4C7:8DAA:D2A5:F10A (talk) 19:36, 2 January 2017 (UTC)
Biochemistry and Structure
I am planning on adding a section that explores the biochemistry that this molecule is involved in and the biochemistry behind it. Nicotinamide is a planar molecule that has a special form of stability called aromaticity.  It is very notable that this molecule is the key active group on NAD+. When it is reduced, this specific part of the molecule loses a high amount of resonance and aromaticity stability, and the reduction process supplies this molecule with a large amount of energy, that it will later release during the citric acid cycle.  JacobShalk (talk) 05:34, 14 February 2017 (UTC)