Talk:Opioid overdose

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Heading[edit]

ANYONE who's familiar with the super-potent NON-HUMAN synthetic opioids, even someone who just has minor experience with tranquilizing/etc rhinos/elephants/etc, please re-word/update anything I may've missed or wrote confusingly. I just wanted to get the "revivon for humans" out of the section before someone finds it at the zoo they're working at, grabs a vial and thinks they have a "safety shot", as it's NOT for humans - it DOES have mu-opioid-AGONIST properties as well as its antagonism, it is meant for getting animals out of, say, a tranquilized state induced by carfentanil or any of the other too-strong-for-human opioids. Revivon isn't even in hospitals for human usage, it comes WITH carfentanil and other super-strong large-animal opioids, to be used after the opioid agonist once moving/tranquilizing/whatever is complete. — Preceding unsigned comment added by SangerRainsford (talkcontribs) 21:29, 2 March 2011 (UTC)

Review[edit]

NEJM this week doi:10.1056/NEJMra1202561. JFW | T@lk 11:57, 12 July 2012 (UTC)

Pharmacodynamics?[edit]

Should there be a section detailing what exactly happens during overdose on a cellular level? My knowledge is sophmoric at best, but is there anyone willing to take on that task? ThanksSuperbuttons (talk) 19:42, 3 July 2013 (UTC)

Opening paragraph weirdness[edit]

" Opioid overdose was responsible for more deaths in the United States from 1999-2008 than heroin or cocaine overdose combined.[1]"

Heroin is an opioid. This sentence doesn't make any sense. LiamSP (talk) 02:26, 9 October 2013 (UTC)

Updated charts. May need to refresh your cache to see 2015 column[edit]

http://refreshyourcache.com/en/cache

Windows: ctrl + F5
Mac/Apple: Apple + R or command + R
Linux: F5

--Timeshifter (talk) 15:21, 29 October 2017 (UTC)

Editing an Existing Article[edit]

I am a nursing student and I have chosen to edit this article. I wanted to include a couple of edits that will ensure that the information presented will be cited properly, and will be much more clear and concise. These are the areas I've chosen to make edits to; "A longer-acting variant of naloxone is naltrexone." I will be citing this statement using the following reliable source.

Lee, J. D., Nunes, E. V., Novo, P., & Bachrach, K. (2017, November). Comparative effectiveness of extended-release naltrexone versus buprenorphine-naloxone for opioid relapse prevention (X:BOT): a multicentre, open-label, randomised controlled trial. The Lancet. doi:10.1016/S0140-6736(17)32812-X

"Other CNS depressants, or "downers", muscle relaxers, pain relievers, anti-convulsants, anxiolytics (anti-anxiety drugs), treatment drugs of a psychoactive or epileptic variety or any other such drug with its active function meant to calm or mitigate neuronal signaling (barbiturates, etc.) can additionally cause a worsened condition with less likelihood of recovery cumulative to each added drug." I will be citing this statement using the following reliable source.

Filter, E., Gorczynkski, L., & Fernandes, J. Fatal Intoxication With a Selective Serotonin Reuptake Inhibitor, Lorazepam, and Codeine.[Report]. American Journal of Forensic Medicine & Pathology, 28(4), 361-363.

"Opioid use disorders resulted in 122,000 deaths globally in 2015 up from 18,000 deaths in 1990." This statement is cited correctly. However, I plan on making just a few changes to the wording of this statement. Initially when I read this statement I was confused, so I hope to rephrase this so it's clearer to the reader. MaddyEngelsma (talk) 18:18, 1 December 2017 (UTC)

Please read WP:MEDRS and WP:MEDMOS Doc James (talk · contribs · email) 22:16, 1 December 2017 (UTC)

Peer Review of Article[edit]

This article is well-written and for the most part provides a comprehensive look at opioid overdoses. There are a few additions that I would suggest: the physiology of overdose and what drug-seeking behaviors are. There is mention of drug-seeking behaviors, but there are not examples. The addition of these two things would make this article more well-rounded and give readers a better grasp on the topic. Williann1 (talk) 16:40, 2 December 2017 (UTC)

Caption should describe image[edit]

  6.9–11
  11.1–13.5
  13.6–16.0
  16.1–18.5
  18.6–21.0
  21.1–52.0

Have adjusted it back to this. This content "Of the 64,070 overdose deaths in the US in 2016,[30] opioids were involved in 42,249.[31" is not supported by the image in question and belongs in the text of the article. We have color coding that tells us the 5 states with the highest number Doc James (talk · contribs · email) 08:35, 15 October 2018 (UTC)

That info is supported by the references. And the total overdose deaths provides context to the map. As do the specific numbers for the highest states. Especially since the map legend ranges are wide it is important to see some specific numbers for the highest states.
But I prefer your placement of the text just above the chart and map, because it makes the chart and map fit better aesthetically on the page.
If the map was by itself then combining the map legend and text as shown below is much more informative. People often go back to such maps to get the big picture fast.
For various examples of combining the map legend and map caption see the description on the Commons page:
Commons:File:US map of drug overdose deaths per 100,000 population by state.gif
I link to that Commons map page from Commons:Map resources
Here is my original format below (from this diff):

Epidemiology

Of the more than 72,000 overdose deaths in the US in 2017, opioids were involved in over 49,000.[1] This is a dramatic increase from 2016 where over 64,000 died from drug overdose, and opioids were involved in over 42,000.[2]

  6.9–11
  11.1–13.5
  13.6–16.0
  16.1–18.5
  18.6–21.0
  21.1–52.0
Of the 64,070 overdose deaths in the US in 2016,[2] opioids were involved in 42,249.[3] In 2016, the five states with the highest rates of death due to drug overdose were West Virginia (52.0 per 100,000), Ohio (39.1 per 100,000), New Hampshire (39.0 per 100,000), Pennsylvania (37.9 per 100,000) and Kentucky (33.5 per 100,000).[3][2]
US yearly overdose deaths, and the drugs involved. Among the more than 72,000 deaths estimated in 2017, the sharpest increase occurred among deaths related to fentanyl and synthetic opioids (more than 29,000 deaths).[1]

References

  1. ^ a b Cite error: The named reference NIDA-deaths was invoked but never defined (see the help page).
  2. ^ a b c National Center for Health Statistics. "Provisional Counts of Drug Overdose Deaths, as of 8/6/2017" (PDF). United States: Centers for Disease Control and Prevention. Source lists US totals for 2015 and 2016 and statistics by state.
  3. ^ a b Drug Overdose Death Data. CDC Injury Center. Centers for Disease Control and Prevention. The numbers for each state are in the data table below the map.

--Timeshifter (talk) 10:19, 15 October 2018 (UTC)

This text "Drug overdose deaths in the US per 100,000 people by state" is already at the top of the image. Am trying to get things to fit better. Doc James (talk · contribs · email) 14:17, 15 October 2018 (UTC)

Prevention[edit]

In terms of prevention, my group of pharmacy students would like to add information regarding legislature that tackles opioid prevention. We wanted to research ones that perhaps looked into high-risk individuals, see what other programs are being performed or proposed in other states, a pharmacist's roll in curbing opioid use, and policies similar to or that have stemmed from Florida's pill mill law. Cindynguyeen (talk) 04:08, 16 October 2018 (UTC)

Pharmacy Students: Proposed Wiki Edits[edit]

After reviewing the contents of this article, we would like to make some improvements in the following sections: My teammates will each tackle a different section. -Include a section about CYP inducers/inhibitors[Albert Yang] -Update the Mechanism section(specifically how opioids cause overdose and the science behind it)[Cindy Huynh] -Including information about children and adolescents[Frances Chen] -Adding other opioid overdose treatment (supportive care/therapies etc)[Anthony Lui] Xcindy huynh (talk) 00:43, 17 October 2018 (UTC)