Talk:Parkinson's disease

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Featured article Parkinson's disease is a featured article; it (or a previous version of it) has been identified as one of the best articles produced by the Wikipedia community. Even so, if you can update or improve it, please do so.
Main Page trophy This article appeared on Wikipedia's Main Page as Today's featured article on April 11, 2011.

New Edit Request - July 14 2016[edit]

In the last paragraph of the initial summary 55 million is given as the number of global cases, in Epidemiology it's listed as 7 million. These should be validated and reconciled.

Thanks, (talk) 20:10, 14 July 2016 (UTC)Mike


"The possible roles of sodium and potassium in PD has been reviewed.[1]"

Does not really provide any useful information so I have removed.


  1. ^ Ha, Yonghwang; Jeong, A Jeong; Kim, Youngsam; Churchill, David G. (2016). "Chapter 16. Sodium and Potassium Relating to Parkinson's Disease and Traumatic Brain Injury". In Astrid, Sigel; Helmut, Sigel; Roland K.O., Sigel. The Alkali Metal Ions: Their Role in Life. Metal Ions in Life Sciences. 16. Springer. pp. 585–601. doi:10.1007/978-4-319-21756-7_16. 

--Doc James (talk · contribs · email) 14:46, 28 May 2016 (UTC)


Mohammed Ali, Michael J. Fox and David Phinney are listed as people through whom public awareness increased. I don't know if the author failed to list Pope John Paul II because the Pope didn't choose to become an activist for Parkinson's, but I dare say that his bout with Parkinson's was far more famous, even in the English-speaking world, than David Phinney's! — Preceding unsigned comment added by (talk) 21:11, 15 August 2016 (UTC)

Semi-protected edit request on 30 August 2016[edit]

{{edit semi-protected} I would like to amend the depression and anxiety section, while there is some evidence that PD is associated with depression and anxiety, there is also a LOT of research which does not show any correlations, I would like to present examples of such research. Please let me know if I can proceed and how)} All-Ku (talk) 18:00, 30 August 2016 (UTC)

We cite content about health to recent (last five years) literature reviews published in good journals or statements by major medical/scientific bodies, per WP:MEDRS. Would you please provide the sources you would like to cite? Jytdog (talk) 18:11, 30 August 2016 (UTC)
There have been peer-reviewed journal articles. Here are some of the sources: This is a large meta-analysis which shows that the prevalence rates are approximately 10% higher in those with Parkinson's disease, than the general population. However, here is another study, which is a peer-reviewed study of the NIHS database which does not show such correlations between depression and PD. This particular study used a disabled comparison group. Thus, these studies together show marginal relationships between depression and PD. I was hoping to provide percentage data, and potential other mechanisms (e.g. disability), in spite of theoretical relationships of Dopamine and NE being responsible for these potential relationships. This is newer research. Therefore, I am only trying to provide a fuller picture. ) — Preceding unsigned comment added by All-Ku (talkcontribs) 18:25, 30 August 2016 (UTC)
the first source is very much the right kind (systematic review plus meta-analysis in high quality journal) but is 9 years old; the second is a primary source from a low quality journal. Neither of these is what we look for. Jytdog (talk) 18:36, 30 August 2016 (UTC)
using this pubmed search, some more recent high quality sources include PMID 24190780 (2013); PMID 24239733 (2014); PMID 24780824 (2014); PMID 25313989 (2014); PMID 25724804 (2015) Jytdog (talk) 18:46, 30 August 2016 (UTC)
someone needs to fix this article then with better sources, so if you can flag it, then please do so. I do not have the time, but currently it is not fully accurate. Many studies being cited are not differentiating apathy and depression when determining the 1/3 prevalence rates; there are no newer meta-analyses that I could locate. The prevalence rates are variable by studies and thus are best addressed by meta-analytic procedures. Also that study I mentioned included apathy and disability as factors in the analyses; these are now considered separate constructs which the DSM may not distinguish. Therefore, someone please edit this page with more time and care in regards to depression and apathy in PD. It needs work — Preceding unsigned comment added by All-Ku (talkcontribs) 18:53, 30 August 2016 (UTC)
Thanks for noting that stuff; we will see what we can do! Jytdog (talk) 19:42, 30 August 2016 (UTC)

Additions to "Prevention"[edit]

I would like to add the following to the "Prevention" section:

Meta-analyses have confirmed that tobacco use is associated with a lower incidence of Parkinson's disease (Noyce et al., 2012). In studies of the effects of secondhand smoke on the incidence of Parkinson's, children exposed to parents' cigarette smoke had a 27% lower risk of Parkinson's (O'Reilly et al., 2009), and risk was inversely related to years exposed in nonsmokers (Nielsen et al., 2012). It has been suggested that nicotine derived from the Nicotiana species of the Solanaceae family of plants, which includes Capsicum and Solanum species (peppers, tomatoes, potatoes, and eggplants), may also be beneficial in reducing Parkinson's risk without the harmful effects of cigarette smoke (Nielsen et al., 2013), though further research is needed to strengthen this causal inference.

Nielsen, S. S., Franklin, G. M., Longstreth, W. T., Swanson, P. D., & Checkoway, H. (2013). Nicotine from edible Solanaceae and risk of Parkinson disease. Annals of Neurology, 74(3), 472–477.

Nielsen, S. S., Gallagher, L. G., Lundin, J. I., Longstreth, W. T., Jr., Smith-Weller, T., Franklin, G. M., . . . Checkoway, H. (2012). Environmental tobacco smoke and Parkinson's disease. Movement Disorders, 27(2), 293–296.

Noyce, A. J., Bestwick, J. P., Silveira-Moriyama, L., Hawkes, C. H., Giovannoni, G., Lees, A. J., & Schrag, A. (2012). Meta-analysis of early nonmotor features and risk factors for Parkinson disease. Annals of Neurology, 72(6), 893–901.

O’Reilly, E. J., Chen, H., Gardener, H., Gao, X., Schwarzschild, M. A., & Ascherio, A. (2009, March 15). Smoking and Parkinson's disease: Using parental smoking as a proxy to explore causality. American Journal of Epidemiology, 169(6), 678–682.

Thank you!

ErinMOBrien (talk) 21:59, 13 September 2016 (UTC)

We really rely on PMIDS - listing them below
Nielsen 2013 = PMID 23661325 PMC 4864980 - primary source, not OK per MEDRS
Nielsen 2012 = PMID 22095755 PMC 3289937 - primary source, not OK per MEDRS
Noyce 2012 = PMID 23071076 PMC 3556649 - secondary source, OK per MEDRS
O'Reilly 2009 = PMID 19131566 PMC 2727210 - primary source, not OK per MEDRS
I'll have a look at the Noyce paper. Thanks! Jytdog (talk) 22:14, 13 September 2016 (UTC)

See also[edit]

IMHO there should be a See also section that includes People with Parkinson's or the IMHO cumbersomely-named article to which it redirects. From common sense and from previous discussions on this page, readers have an interest in knowing who is or has been afflicted by Parkinson's. A few of them, e.g. Muhammad Ali and Michael J. Fox are well-known individuals who are widely known to be Parkinson's sufferers. There are many more individuals who are notable but not widely known to have Parkinson's. Lou Sander (talk) 00:37, 16 September 2016 (UTC)

just argh. Jytdog (talk) 00:44, 16 September 2016 (UTC)

Semi-protected edit request on 20 September 2016[edit]

A new technology called high intensity focused ultrasound has recently been used to treat tremor in patients with Parkinson's disease. With this new method ultrasound waves are focused to the thalamus and thus cause thalamotomy through an intact skull without any incisions, without a burr hole and without implantation of a pacemaker. This procedure uses MRI guidance in order to localize the thalamus. The ultrasound waves cause gradual warming of the tissue until there is ablation, seen clinically as resolution of tremor. During the procedure the patient is awake. Thus if there are any adverse effects, the area of the thalamus that is treated can be adjusted before there is ablation. Favorable responses have so far been reported in Parkinson's disease patients followed for up to two years. [?]

Schlesinger I, Eran A, Sinai A, Erikh I, Nassar M, Goldsher D, Zaaroor M. MRI Guided Focused Ultrasound Thalamotomy for Moderate-to-Severe Tremor in Parkinson's Disease. Parkinsons Dis. 2015; 2015:219149. doi: 10.1155/2015/219149. Epub 2-Sep-2015Mariatsiounas (talk) 11:52, 20 September 2016 (UTC)Cite error: A <ref> tag is missing the closing </ref> (see the help page). </ref>

Thanks for your suggestion! The sourcing guideline for content about health is WP:MEDRS - it says that we use literature reviews published in good journals or statements from major medical/scientific bodies. The source you provide there is a research article and we can't use that. Best regards Jytdog (talk) 12:08, 20 September 2016 (UTC)


Also, in the paper of reference 9, on page 31, the "Prevalent cases in 2013 (× 1000)" for PD is 5866·3, which is about 5.8 million, rather than 55 million. The difference is huge. Could somebody double check this number? — Preceding unsigned comment added by (talkcontribs) 13:56, 11 October 2016 (UTC)

Expert review[edit]

Ok then, see this. Let's start looking at these and implementing....Cas Liber (talk · contribs) 06:17, 20 October 2016 (UTC)

  • Regarding their first point, a summary of the use of the term paralysis agitans seems important to add. Reading this. Cas Liber (talk · contribs) 06:22, 20 October 2016 (UTC)
IMO a discussion of the term belongs in the body not the lead. We already have the term in the infobox which is sufficient their. In the first sentence is undue weight. Doc James (talk · contribs · email) 20:13, 20 October 2016 (UTC)
Ok, it was an important term but is mainly a historical one (surprised it is still used in coding). One expert wants it in, but everyone else wants it out of the lead. I could go either way. So it's an out then. I do think a sentence or two more on the use of the term is important for the History section though. OTOH, might start by including it at History of Parkinson's disease, where it is not discussed much either and work backwards. I do note this article is at 51 kb prose now...Cas Liber (talk · contribs) 12:35, 25 October 2016 (UTC)
The more I think about the size of the parent article, the more I am content to leave in the daughter article, which I have added to. Cas Liber (talk · contribs) 12:55, 25 October 2016 (UTC)
Sounds good. Doc James (talk · contribs · email) 18:55, 25 October 2016 (UTC)