|WikiProject Molecular and Cell Biology||(Rated Start-class, Low-importance)|
The picture shown is for complement-mediated lysis, not perforin. Should it be changed? Wedgeoli 15:55, 11 December 2006 (UTC)
Hi - the picture is intended to illustrate the fold of the MACPF domain, which is the lytic part of perforin (perforin also contains an EGF and a C2 domain, the latter domain is probaby positioned in a similar fashion to the beta-prism domain of Plu-MACPF). Complement proteins such as C6-C9 also have the same MACPF domain type as their lytic centre - hence this type of picture could be used to illustrate both families. I therefore feel that the picture is useful to illustrate the perforin page - it obviously would be better to shoulw a perforin structure, but unfortunately that as not been solved yet! Jcwhizz 15:57, 20 September 2007 (UTC)
There are two hypothesises(sp?) as to how Perforin helps granzyme enter the cell, pore formation is only one of them, the other hypothesis is that it somehow induces the target cell to endocytose the granzyme molecules, and that pore formation, if it does happen, only occurs at high concentrations of Perforin.
outlined here: http://www.nature.com/nri/journal/v6/n12/full/nri1983.html Perforin-mediated target-cell death and immune homeostasis, Voskoboinik et al, (2006)Nature Reviews Immunology 6, 940-952. Philman132 (talk) 11:45, 26 April 2009 (UTC)
Link to news article of results of 10 year study: http://www.financialexpress.com/news/Scientists-find---assassin---protein-that-kills-rogue-cells/705606/ —Preceding unsigned comment added by 18.104.22.168 (talk) 04:10, 3 November 2010 (UTC)