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This article is too focused on human and mammalian stem cells, and should leave those topics to specialized articles on those topics (and stem cell therapy / research). The Plant_stem_cell article should be merged with this one so that the single topic is covered in a single article. 126.96.36.199 (talk) 03:19, 25 February 2014 (UTC)
The follow section is mostly unsourced, and what is sourced, is sourced from the research paper announcing the finding. This is a violation of WP:NPOV and WP:OR, since we need secondary sources saying that the event mattered - editors cannot determine that. I cut it from the article and am pasting here for discussion...
1908: The term "stem cell" was proposed for scientific use by the Russian histologist Alexander Maksimov (1874–1928) at congress of hematologic society in Berlin. It postulated existence of haematopoietic stem cells.
1960s: Joseph Altman and Gopal Das present scientific evidence of adult neurogenesis, ongoing stem cell activity in the brain; their reports contradict Cajal's "no new neurons" dogma and are largely ignored.
1963: Becker, McCulloch and Till illustrate the presence of self-renewing cells in mouse bone marrow.
1995: Indian scientist Dr. B.G. Matapurkar pioneers in adult stem-cell research with clinical utilization of research in the body and neo-regeneration of tissues and organs in the body. Received International Patent from US Patent Office (USA) in 2001 (effective from 1995). Clinical utilization in human body also demonstrated and patented in 60 patients (World Journal of Surgery-1999 and 1991).
1997: Dr. B.G. Matapurkar's surgical technique on regeneration of tissues and organs is published. Regeneration of fallopian tube and uterus is published.
1997: Leukemia is shown to originate from a haematopoietic stem cell, the first direct evidence for cancer stem cells.
2005: Researchers at Kingston University in England claim to have discovered a third category of stem cell, dubbed cord-blood-derived embryonic-like stem cells (CBEs), derived from umbilical cord blood. The group claims these cells are able to differentiate into more types of tissue than adult stem cells.
2005: Researchers at UC Irvine's Reeve-Irvine Research Center are able to partially restore the ability of rats with paralyzed spines to walk through the injection of human neural stem cells.
June 2007: Research reported by three different groups shows that normal skin cells can be reprogrammed to an embryonic state in mice. In the same month, scientist Shoukhrat Mitalipov reports the first successful creation of a primate stem cell line through somatic cell nuclear transfer
Martin Evans, a co-winner of the Nobel Prize in recognition of his gene targeting work.
November 2007: Human induced pluripotent stem cells: Two similar papers released by their respective journals prior to formal publication: in Cell by Kazutoshi Takahashi and Shinya Yamanaka, "Induction of pluripotent stem cells from adult human fibroblasts by defined factors", and in Science by Junying Yu, et al., from the research group of James Thomson, "Induced pluripotent stem cell lines derived from human somatic cells": pluripotent stem cells generated from mature human fibroblasts. It is possible now to produce a stem cell from almost any other human cell instead of using embryos as needed previously, albeit the risk of tumorigenesis due to c-myc and retroviral gene transfer remains to be determined.
January 2008: Robert Lanza and colleagues at Advanced Cell Technology and UCSF create the first human embryonic stem cells without destruction of the embryo.
February 2008: Generation of pluripotent stem cells from adult mouse liver and stomach: these iPS cells seem to be more similar to embryonic stem cells than the previously developed iPS cells and not tumorigenic, moreover genes that are required for iPS cells do not need to be inserted into specific sites, which encourages the development of non-viral reprogramming techniques.
March 2008-The first published study of successful cartilage regeneration in the human knee using autologous adult mesenchymal stem cells is published by clinicians from Regenerative Sciences
1 March 2009: Andras Nagy, Keisuke Kaji, et al. discover a way to produce embryonic-like stem cells from normal adult cells by using a novel "wrapping" procedure to deliver specific genes to adult cells to reprogram them into stem cells without the risks of using a virus to make the change. The use of electroporation is said to allow for the temporary insertion of genes into the cell.
28 May 2009 Kim et al. announced that they had devised a way to manipulate skin cells to create patient specific "induced pluripotent stem cells" (iPS), claiming it to be the 'ultimate stem cell solution'.
11 October 2010 First trial of embryonic stem cells in humans.
25 October 2010: Ishikawa et al. write in the Journal of Experimental Medicine that research shows that transplanted cells that contain their new host's nuclear DNA could still be rejected by the individual's immune system due to foreign mitochondrial DNA. Tissues made from a person's stem cells could therefore be rejected, because mitochondrial genomes tend to accumulate mutations.
2011: Israeli scientist Inbar Friedrich Ben-Nun led a team which produced the first stem cells from endangered species, a breakthrough that could save animals in danger of extinction.
October 2012: Positions of nucleosomes in mouse embryonic stem cells and the changes in their positions during differentiation to neural progenitor cells and embryonic fibroblasts are determined with single-nucleotide resolution.
2012: Katsuhiko Hayashi used mouse skin cells to create stem cells and then used these stem cells to create mouse eggs. These eggs were then fertilized and produced healthy baby offspring. These latter mice were able to have their own babies.
2013: First time lab grown meat made from muscle stem-cells has been cooked and tasted.
2013: First time mice adult cells were reprogrammed into stem cells in vivo.
2014: Adult mouse cells reprogrammed to pluripotent stem cells using stimulus-triggered acquisition of pluripotency (STAP); a process which involved bathing blood cells in an acid bath (pH 5.7) for 30minutes at 37 °C. A little over a month after the publication of these findings, errors were discovered and the quality of the research has been widely questioned. Further irregularities regarding the mice used have emerged as recently as June 2014.
^Matapurkar BG, Bhargave A, Dawson L, Sonal B (1999). "Regeneration of abdominal wall aponeurosis: New dimension in Marlex peritoneal sandwich repair of incisional hernia". World journal of surgery23 (5): 446–450; discussion 450. doi:10.1007/PL00012326. PMID10085391.
^Matapurkar BG, Gupta AK, Agarwal AK (1991). "A new technique of "Marlex-peritoneal sandwich" in the repair of large incisional hernias". World journal of surgery15 (6): 768–770. doi:10.1007/BF01665314. PMID1767543.
^Mitalipov SM, Zhou Q, Byrne JA, Ji WZ, Norgren RB, Wolf DP (2007). "Reprogramming following somatic cell nuclear transfer in primates is dependent upon nuclear remodeling". Hum Reprod22 (8): 2232–42. doi:10.1093/humrep/dem136. PMID17562675.
^Chung Y, Klimanskaya I, Becker S, Li T, Maserati M, Lu SJ, Zdravkovic T, Ilic D, Genbacev O, Fisher S, Krtolica A, Lanza R (2008). "Human Embryonic Stem Cell Lines Generated without Embryo Destruction". Cell Stem Cell2 (2): 113–117. doi:10.1016/j.stem.2007.12.013. PMID18371431.
^Conrad S, Renninger M, Hennenlotter J, Wiesner T, Just L, Bonin M, Aicher W, Bühring HJ, Mattheus U, Mack A, Wagner HJ, Minger S, Matzkies M, Reppel M, Hescheler J, Sievert KD, Stenzl A, Skutella T (2008). "Generation of pluripotent stem cells from adult human testis". Nature456 (7220): 344–9. Bibcode:2008Natur.456..344C. doi:10.1038/nature07404. PMID18849962.
^Bazian (30 January 2014). NHS Choices, ed. "Breakthrough in stem cell creation using acid bath". U.K. National Health Service. Retrieved 2014-02-06. They put them in a weak acid solution (pH 5.7) for 30 minutes at 37°C, and then put them into petri dishes and grew them at normal pH.