|WikiProject Chemicals / Core||(Rated Start-class, Mid-importance)|
|WikiProject Molecular and Cell Biology||(Rated B-class, High-importance)|
Normally i'm not the greatest fan of over-merging, but T4 and T3 are normally used interchangably (or at least at the same time), and the differences are probably best discussed on the one page.
If anyone's strongly opposed speak now. Or just reverse it later :-) tb 00:12, 21 Mar 2004 (UTC)
- They are different chemically, and I would not merge thyroxine and tri-iodothyronine. It is an over simplification to consider thyroxine as only a pro-hormone. The pituitary thyroxine receptor appears to be more specific for thyroxine than T3. Thyroxine itself does have a few actions distinct from being a source of T3, and is also probably the major hormone controlling development in amphibians. I would use this page as a chemical description of thyroxine, and have discussionss on physiology, gopiter, animals and comparative endocrinology on there separate pages. You can always click on "What links here".Pustelnik 00:42, 13 July 2007 (UTC)
I find this page to be far too brief. No discussion of the physiological role of these hormones? I think it needs to be expanded via links----184.108.40.206 15:37, 1 March 2007 (UTC)
What is relationship between thyroxine, dietary iodine, and goiters? 220.127.116.11 05:11, 4 March 2007 (UTC)
This article is not even start level, it can only be a stub. Somebody tag this article please. 18.104.22.168 15:47, 29 March 2007 (UTC)
The diagram at the bottom is confusing, since it shows the conversion and not the synthesis of Thyroxine. It would be interesting to show the synthesis plan for Thyroxin like it is done for epinephrine or serotonin. --Weeddude 10:15, 6 October 2007 (UTC)
- I agree. I have in the meantime changed the caption to "Transformations". Eric Kvaalen (talk) 17:51, 14 April 2008 (UTC)
I think levothyroxine should be merged into this article. The two articles discuss exactly the same substance, one as a hormone, the other as a drug. I don't think there is a sufficiently good reason to separate them, and a lot of information which is in the articles (or should be) should be in both, which would cause even more overlap. Eric Kvaalen (talk) 17:51, 14 April 2008 (UTC)
These two articles must be merged. There is a lot more information that needs to be added, particularly the physiological actions of thyroxine, its regulation etc.Prakashmalshe (talk) 03:31, 15 May 2008 (UTC) Dr. Prakash C. Malshe.
It would be senseless to merge an article for what is essentially a drug to that of a naturally occuring compound. By all means maintain a link between the two though they are clearly two separate entities and should remain so, so as not to confuse people. —Preceding unsigned comment added by 22.214.171.124 (talk) 11:21, 19 June 2008 (UTC)
I agree that the articles should be merged. In addition, the body's feedback and regulation system for thyroxine should be described, including the feedback duration. It would be nice to see a section somewhere about the side effects, eg palpitations, nad how these can be explained. For example, in my own case, I am in early stage hypothoidism, my natural level of T4 is okay but I have very high TSH. I began a course of low dose levothyroxine and started having palpitations. Given that the drug should only have replaced natural thyroxine, which, because of the feedback mechanism, should now have been produced in a lower concentration, why should I have this side effect? Connor Birch 'Spookey' —Preceding unsigned comment added by Spookey (talk • contribs) 07:43, 23 June 2008 (UTC)
I would like to see them kept separate, so it is easier to understand the difference between the natural hormone and the synthetic drug - for those trying to understand and manage medications. Esurra (talk) 15:29, 10 July 2008 (UTC)
The structures given actually describe two different chemicals since levothyroxine is given as a single enantiomer and thyroxine is racemic. I disagree as to the merger anyway as it confuses the functions of a hormone and a drug, though physiologically their function may be the same in human terms they are very different. Drugs deserve their own entries to discuss their importance as a drug for the benefit of suffers of the disease. In this case a widespread one with upwards of 2 percent of western populations suffering from hypothyroidism. - Anthony, August 2008 —Preceding unsigned comment added by 126.96.36.199 (talk) 13:59, 31 July 2008 (UTC)
I strongly oppose the merge. Thyroxine and Levothyroxine are different substances and they are used quite differently. Additionally, Levothyroxine contains ingredients other than the hormone and some people get side-effects from those additives. The two are not chemically identical. And due to their functional differences, they should be described and categorized quite differently. One is a natural hormone. The other is a synthetic medicine. They have different names, different origins, different applications, different chemical makeups, and are in all other ways two distinctly separate entities. Furthermore, there is very little redundant information between the articles. There's no reason to merge them. Svadhisthana (talk) 09:45, 9 August 2008 (UTC)
- It's been four months since the merger proposal and nothing's changed. I'm removing the proposal. If someone has a reasonable argument for reconsidering the merger, it can be rediscussed here. svadhisthana (talk) 17:28, 13 August 2008 (UTC)
- Please support your statements. You have simply denied everything I wrote, without justifying anything. Why do you say that natural thyroxine and levothyroxine are different substances? What is the difference? Eric Kvaalen (talk) 13:36, 19 February 2012 (UTC)
- Please reverse this merger. The simplest and most important reason is that aside from it's function as a thyroid hormone thyroxine is simply a chemical compound that should have its own article. For instance, go look at the triiodothyronine page and you'll see the standard chemical description page there with molecular weight, chemical formula, IUPAC name, etc. - a wealth of information uninteresting to and therefore absent from the thyroid hormone page this link now redirects to. The original thyroxine page should be restored with all of this chemical information. Regarding some of the above discussion - it is true that thyroxine produced in the thyroid can be either enantiomer and that the isolated levo-thyroxine enantiomer is what is in the drug. This is specifically interesting because levothyroxine can only be converted to "normal" T3, not "reverse" T3 - which is the other enantiomer. This has physiological consequences for those on the drug. So I think this is good information that we should add to the Thyroxine page once it is restored - but I don't think a separate page is needed for that. We just need the separate Thyroxine page back to have a place for that information to go - along with all of the now absent chemical information since merger with the Thyroid Hormones article. How do we/who can reverse this? Thanks...188.8.131.52 (talk) 18:49, 10 August 2015 (UTC)mjd
T4 and cold?
I saw an episode of Brainiac today, and in this episode, they "demonstrated" (i take their demonstrations with a grain of salt) how low temperatures highten our perception of pain. They've explained this by saying that when the body detects low temperatures, the thyroid reacts by secreting larger doses of thyroxine, which makes the nerves more sensitive to pain.
I'm a layman, and so i don't know if this is factual. My point in telling this, is that information on the physiological effects of T4 seems to be missing from the article, although the article vaguely states that "T4 is involved in controlling the rate of metabolic processes in the body and influencing physical development", it is not clear what these metabolic processes are, and what kind of an influence it has on physical development.
- I suggest you add what you know/find to the article, with references of course. Generally speaking this article is unacceptably brief especially since its already been around for more than 3 years. Jahibadkaret (talk) 12:05, 19 November 2010 (UTC)