Talk:Torcetrapib

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'First in man' vs. 'First in humans' (industry colloquialism)[edit]

An editor recently change the passage 'first administered in man in 1999' to 'first administered in humans in 1999'. I'm not going to revert this change, but I will point out that the commonly referred to milestone in the pharmaceutical industry is 'First time in man' and not 'First time in humans'. It is an industry colloquialism. Regards, --User:Ceyockey (talk to me) 23:25, 3 December 2006 (UTC)

Actually Pfizer has for at least 5 years used the term FIH ("first [time] in human") to refer to the milestone, which is laudable as in the 21st century it's about time we moved to more gender-neutral language.68.43.123.215 06:51, 28 February 2007 (UTC)anon

The MedlinePlus link is no longer functioning.

CMT[edit]

It is definitely off the map now: doi:10.1016/S0140-6736(07)61088-5 JFW | T@lk 08:24, 15 July 2007 (UTC)

Used that in the article now. Rod57 (talk) 18:14, 13 March 2011 (UTC)

Synthesis[edit]

doi:10.1055/s-2006-942056 JFW | T@lk 15:43, 4 November 2007 (UTC)

What analysis of reasons for failure[edit]

Can anyone refer to discussions of how/why it had the adverse effects ?
Has the failure damaged the low HDL or HDL:LDL theory of CVD ? Rod57 (talk) 18:18, 13 March 2011 (UTC)

A slightly off mainstream critique: Wherefore Art Thy Protection, O HDL?. Basic point made by the author is that while HDL cholesterol is a good marker in his view it does not necessarily have any causal relation to CVD and should not be confused with HDL itself. To quote:

The medical field has created enormous confusion by conflating "HDL" with "HDL-cholesterol." When you go to the doctor and get bloodwork, they do not test your "LDL" and your "HDL." They test the amount of cholesterol contained in these lipoproteins. But they call your LDL-cholesterol your "LDL" and they call your "HDL-cholesterol" your "HDL."

When I say I do not believe that the epidemiological associations with HDL-cholesterol are causal, this does not mean that I do not believe that the HDL particle is protective. It is. But the evidence suggests that it is protective because of its highly specific role in delivering vitamin E to endothelial cells, not becuase of its role in reverse cholesterol transport. And guess what? CETP blockers directly undermine this process!

Lambanog (talk) 09:30, 27 April 2011 (UTC)
@Lambanog: Thanks (belatedly) for that blog link - very interesting. I'll try to find some RS. - Rod57 (talk) 10:27, 10 March 2016 (UTC)

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