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What's about Vaccination?[edit]

Is this Toxoplasmosis article here only "human related"? I have added the following information to the Toxoplasma gondii article, can it be also noted here?

As of 2015, no approved human vaccine exists against Toxoplasma gondii.[1]

For sheep there is available an approved live vaccine called Toxovax (MSD Animal Health) which provides lifetime protection.[2]

lion10 (talk) 10:26, 11 November 2015 (UTC)

Symptoms section needs to be rewritten to be about symptoms[edit]

It says:

Latent toxoplasmosis[edit] It is easy for a host to become infected with Toxoplasma gondii and develop toxoplasmosis without knowing it. In most immunocompetent people, the infection enters a latent phase, during which only bradyzoites are present,[16] forming cysts in nervous and muscle tissue. Most infants who are infected while in the womb have no symptoms at birth, but may develop symptoms later in life.[17]

When you read this, instead of telling you signs and symptoms, it tells you what the parasites are doing and the fact that babies infected in the womb can have no symptoms and might develop symptoms later on. The problem is that this section doesn't actually tell you any of the symptoms/signs, and it especially doesn't tell you symptoms/signs for someone who got the parasite while free from his womb.

Overall feedback on this article[edit]

I do not believe this was written by a professional. The writing itself is poorly organized, but more importantly there are crucial aspects that are not addressed, or addressed incorrectly. What is troubling about that is for example the conseuences of Toxoplasmosis contracted congenitally. The article glosses over this as if it is rarely a problem which is not true; a medical professional would emphasize what is relevant about this infection, and first on the list in terms of morbidity and mortality is the conseuences of congenital infection (in a previously negative pregnant woman). The conseuences in this situation are well known and common. The majority of the article focuses on science that is far less documented and accepted, and arguably less conseuential in terms of morbidity and mortality.... Throughout the article simple obvious things are not clarified eg.when the author is speaking of colonization of an individual versus active infection. This is an important distinction to make. The article is seemingly written for someone with significant prior knowledge of the subject. Because this is a Wikipedia article and is presumably for laypeople, the article should be written so that it can be followed by an average person and it is not. The overall article shares dubious studies but worse than that it does not effectively address anything critical concerning the relatively new area of "crazy cat lady" research. The overall article is biased and then goes on to tack on a disclaimer of sorts at the end. ... This article is focused on Toxoplasmosis and not on T. gondii specifically. So I wonder if the implication should be that, as this article focuses on a specific well recognized manifestation of infection, with a proper medical name attached to it, if perhaps the speculation about other possible complications from the particular organism, should be moved to the T.gonddi page. ...The whole article needs to be rewritten and is not salvageable.A medical professional might be ideal. ? Most Wikipedia entries are very useful and informative. — Preceding unsigned comment added by 43&*H()BVsd5ercdv8yu (talkcontribs) 08:05, 17 September 2014 (UTC)

Epigenetics, inclusion of sources that do not mention toxoplasmosis[edit]

I don't understand why my removal of this passage was reverted: [1]. The three sources cited for this claim--"Similar epigenetically-induced behavioral changes have also been observed in mouse models of addiction, where changes in the expression of histone-modifying enzymes via gene knockout or enzyme inhibition produced neuron-specific alterations in drug-related behaviors"--were used to strengthen the argument that epigenetic remodeling of rat amygdala is the mechanism by which T. gondii alters behavior. However, none of the sources makes this argument or even mentions toxoplasmosis/T. gondii. The next sentence--"Widespread histone-lysine acetylation in cortical astrocytes appears to be another epigenetic mechanism employed by T. gondii"--is followed by two citations. Neither reference claims that histone acetylation is tied to rat behavior. Unless I'm missing something, these two sentences should be deleted. CatPath (talk) 03:43, 3 July 2015 (UTC)

The only thing that sentence suggests, the way I read it, is that behavioral changes which result from changes in the (neuro)epigenome, specifically though histone-lysine acetylation, are not unique to rats. Seppi333 (Insert ) 04:42, 3 July 2015 (UTC)
I see that now. Thanks, I was reading too much into the passage. CatPath (talk) 22:16, 3 July 2015 (UTC)

External links modified[edit]

Hello fellow Wikipedians,

I have just added archive links to one external link on Toxoplasmosis. Please take a moment to review my edit. If necessary, add {{cbignore}} after the link to keep me from modifying it. Alternatively, you can add {{nobots|deny=InternetArchiveBot}} to keep me off the page altogether. I made the following changes:

When you have finished reviewing my changes, please set the checked parameter below to true to let others know.

N Archived sources still need to be checked

Cheers. —cyberbot IITalk to my owner:Online 00:04, 29 August 2015 (UTC)

  1. ^ "Development of Toxoplasma gondii vaccine". US National Library of Medicine. 2013-02-01. Retrieved 2015-11-10. 
  2. ^ "TOXOVAX®". MSD Animal Health. Retrieved 2015-11-10.