Talk:Transient receptor potential channel
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|This article is or was the subject of a Wiki Education Foundation-supported course assignment, between 4 September 2018 and 20 December 2018. Further details are available on the course page. Assigned student editor(s): DBM393. Assigned peer reviews: ApexofAdharma, DK2975.|
There is a real need to make clear to what "transient" refers in a transient receptor potential, and the advice of the wider community is solicited to fill this need. The corresponding acronym, TRP, is appended to at least three classes of ion channel, which mediate the response of a cell to external stimuli (electrical charge, substances, and forces) by increasing or decreasing its selective permeability to particular ions. The effect of this change is to modify the potential difference between inside and outside of cell. Hence "receptor," for sensitivity to the environment, and "potential" for this difference. Does the "transience" suggest fatigue effects? Or, are there any "invariant receptor potentials" that need compared?
The explanation of the meaning of the acronym TRP is quite innacurate. In a normal fly, the photons stimulating the photoreceptors in the eye cause a sustained elevation in the electric potential of the cell. However, there is a mutant strain of Drosophila flies that becomes blind after long exposure to light. It was detected that in this particular mutant, the elevation in the potential of the cell after exposure to light was transient and not sustained. The mutant was then named Transient Receptor Potential (TRP), although at the time the cause for this defect was unknown (Cosens and Manning, 1969). Several years later a mutation in a putative channel was found to be responsible for this defect, and thus the channel was named TRP. (Montell, C. and Rubin, G. M., 1989 and Hardie, R. C. and Minke, B. 1992). Similar channels have been since cloned in a wide variety of organisms ranging from yeast to mammals. In a wide variety of cells there are several channels (other than TRPs) that can be activated in response to external stimuli, and they all change the cell potential. TRP refers only to a family of proteins with related sequence and structure, not to the means of activation of these proteins. 18.104.22.168 03:19, 8 November 2005 (UTC)
Reverted edits by 22.214.171.124
Activation of TRP channels
"It was found that a lipid product of PLC cascade, diacylglycerol (DAG), can directly activate TRP channels thus initiating membrane depolarization in response to light" - This claim is not supported by the reference given, indeed this reference states that breakdown of DAG by DAG Lipase is required for Trp activation. I have corrected the statement. Silasmellor (talk) 09:47, 1 April 2010 (UTC)
Should be noted that the work of Leung is controversial. The inaE gene product is not localised to the rhabdomere, so it is unlikely to be directly involved in the signalling cascade.
Also, Leung mentions that inaE is an SN-1 lipase. There is no suggestion in the literature whatsoever that SN-1 products are able to activate the channel. — Preceding unsigned comment added by 126.96.36.199 (talk) 18:27, 4 April 2015 (UTC)
Location / cell types?
I will be adding a table of location and cell types that the different TRP channels are found in, as well as a graphic of the order of different TRP channels and their functions. This will be happening in the coming weeks. DBM393 (talk) 18:16, 1 December 2018 (UTC)
Wrong PubMed IDs
This article contains material copied over from TRPV and has inherited its problems. There are citations with PubMed IDs 3129667 and 2683630 which are obviously not relevant to TRPs at all (radiosurgery and asthma, respectively). It would appear that the IDs were mistyped, and then a bot fetched the metadata for those IDs, and then nobody noticed for three years. Somebody should find sources that are actually relevant and actually support the statements for which these articles are cited, and replace all those citations. Junkyardprince (talk) 04:12, 24 August 2017 (UTC)
I really like the "subfamilies" section. It serves as a nice list compiling information about the different types of trp channels. Maybe also add a figure that addresses the phylogeny and branching of these channels into different "sub-classes." (talk) 22:42, 08 May 2019 (UTC)
I recommend adding a figure that shows how the channel looks like for group 1 and group 2. (talk) 22:42, 08 May 2019 (UTC)
Make sure to cite what was written on the second paragraph in this sub-section. Are you sure that TRPA1 channels respond to those substances? If so, explain what kinds of organisms do those channels function the way you described? And, what cells specifically? For example in Drosophila, trpA1 in gustatory receptor neurons were found to only be sensitive to one bitter compound (Kim et al. 2010). Overall, try not to only list compounds that TRPA1 respond to. Describe where and how as well. (talk) 22:42, 08 May 2019 (UTC)
TRP-like channels in insect vision
This section seems too specific. It could possibly go under an insect vision article or something related. For vision, I recommend inserting it into the "function" section. Since there's pain, temperature sensation, taste, etc. it seems more organized to put "vision" in that section as well. (talk) 22:42, 08 May 2019 (UTC)
The introduction section lists out the various disorders that trp channels are involved in. Maybe add a separate sub-section for each disorder/disease that it's involved in. For example, I suggest adding a section on how trp channels are involved in kidney disorders since it was mentioned in the introduction paragraph for "clinical significance." (talk) 22:42, 08 May 2019 (UTC)