Talk:V(D)J recombination

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Number of VH genes[edit]

This article claims 39 functional VH genes, and a total of 123 VH genes. However, PMID 7779254 claims 51 functional VH genes.

Immunology is a new field and new genes are being discovered all the time. So you should generally go with the most recent article. Both these numbers are probably outdated by now, seeing as they are from 1995 and 1998. Elbonia (talk) 20:27, 8 September 2010 (UTC)

This history might also be interesting for this article. WhatamIdoing (talk) 02:49, 4 May 2008 (UTC)

The antibody repertoire is definitely much larger than 10530, you don't multiply them together, combinations are made from them and as a consequence 10^8 combinations are made, at least. —Preceding unsigned comment added by Rambatino (talkcontribs) 20:42, 29 April 2011 (UTC)

"Nearly Randomly"[edit]

In the intro:

V(D)J recombination nearly randomly combines Variable, Diverse, and Joining gene segments...

Sounds strange. Is this process really random? 184.153.187.119 (talk) 00:52, 7 February 2013 (UTC)

Assessment comment[edit]

The comment(s) below were originally left at Talk:V(D)J recombination/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.

I tentatively graded this as a Class B page since it contains more info than a start article, but it still needs some more background to make it clear to a general audience, and needs a lot of simplfying. Ciar 18:37, 9 August 2007 (UTC)

Last edited at 18:37, 9 August 2007 (UTC). Substituted at 09:45, 30 April 2016 (UTC)

Careful use of terms[edit]

The Background section contains this sentence: "The light chains also possess 2 Constant (Cμ and Cδ) gene segments and numerous V and J gene segments..."

Should this not read "The light chain LOCI..." or perhaps "The genes for the light chains..."? I would think that not only would the LC's not "have numerous V gene segments", but would not have ANY 'gene segments', only sequences encoded by the genes.

It may be obvious to the author, but I'm here because I'm completely naïve and would like to understand it.Captain Puget (talk) 19:40, 23 May 2016 (UTC)