Talk:Warfarin
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Contents
What[edit]
What on earth happened to the Talk page? I am sure one existed before??? 138.37.188.109 11:39, 29 Nov 2004 (UTC)
Bleeds[edit]
I felt that Axel's latest edit seemed to slightly understate the risk from a bleed. I'd hate the article to wrongly reassure someone with a bleed that as they are mostly not important they shouldn't do anything about it. So I have reworded it. The bad news is that my reword is clunky and needs sorting out but I am currently at a loss as to how to do this and not lose the meaning further, so I think I will leave it and hope that someone else will have a go. And where the h*ll is the Talk page??? :) 138.37.188.109 11:46, 29 Nov 2004 (UTC)
- I cannot find an old talk page. Are you perhaps confusing it with a different page? I rephrased your edit. JFW | T@lk 12:55, 29 Nov 2004 (UTC)
- You may be right - I did think there was one, but who knows what I have been bleeding into? :) (me again but not same IP, confusingly)
- Thanks for the rephrase. It's good with one reservation on text and one language. The only lang prob is that ppl are going to misread "proportion" and the singular verb as a mistake. Your English is correct, but I would put money that they'll think it's wrong. :) On text, I still think that what is slightly missing is the message (which for DEEPLY personal reasons I wanted in! :) ) saying "don't assume that ANY bruising and bleeding is trivial unless someone with the right letters after their name has said so, you prat!" - but more nicely! <g> 138.37.188.109
Removed para:[edit]
I removed this:
"Warfarin was first developed for use as a rat poison (whence the proprietary name, from "war-faring" against rodents), where it kills by allowing any minor bleeding to continue unstopped until the animal dies. This use is declining as many rat populations have evolved resistance to warfarin.
It is also used medicinally, in much lower doses, as an anticoagulant."
Firstly, the rat poison element was already dealt with, lower down in the article. The duplciation was confusing.
Secondly, the name derivation is not what I and many others believe to be correct and contradicts the lower part of the article. You can't have both and I would want to see some good evidence for the "warfare" thing before accepting it. I think you will find that the Wisconsin Alumni version is generally held to be correct.
Is there any evidence for rats getting resistant to it? I don't see how this would work but if there is some evidence then we should have it in. 82.35.17.203 00:57, 2 Dec 2004 (UTC)
- Restored immunity sentence (lower down) - there is plenty of evidence for this, sorry. Still don't see how it works! (i.e how does the warfarinised rat survive to pass on the immunity??) :) 82.35.17.203 01:07, 2 Dec 2004 (UTC)
Hi 82.35.17.203 - I'd suspect the aspect of 'warfaring' played a part in the choice of the acronym for the brand name; this sort of punning is popular in selection of brand names. As the use as a rodenticide preceeded medical use (and in the UK at least, is by far the better known of the uses), I think this should be mentioned higher up in the uses paragraph, rather than as a footnote in the history section. Sorry, I don't know how immunity in rats works; what little I do know is that resistance is conferred by a single recessive gene, and that animals inheriting double-recessive are stillborn (so warfarin-resistant rats have small litters; 'AA' rats live but are susceptible to warfarin poisoning, 'Aa' live and resist, and 'aa' are stillborn). I'm sure there's plenty of documentation available, I don't have it myself though - MPF 14:34, 11 Dec 2004 (UTC)
- Hi. With the greatest of respect, your suspicion about the name doesn't add up to documentation of it. The Wisconsin thing is well-documented. I agree that the "warfare" idea is a cute pseudo-explanation, but I have yet to see any more to it than that. I disagree vehemently with your statement that its rodent-control use is "far better known" than the medical one, and I don't think you can assert this without evidence. It's quite simply a question of what you're already familiar with. There are increasing numbers of the elderly and not-so-elderly population on warfarin - those people, and their spouses, children, friends etc know what it is medically. I cannot see how one view can prevail without some evidence and I would be reluctant to alter the article based on a feeling that one of us has and another does not. Gonegonegone 17:52, 3 Feb 2005 (UTC)
Foreign usage[edit]
I live in Sweden. After a pulmonary embolism, I was put on 2.5mg warfarin sodium (Nycomed Waran), in the form of small green tablets. Dosage is monitored with an INR target in the rang 2-3. I'm interested in how this relates to the (presumably American) variants listed.
- The listed variants are based on the British presentation. I'm not sure what the tablet colours are in Sweden. Please find out & add it to the article! JFW | T@lk 02:10, 30 Jan 2005 (UTC)
- Yeah, you bet they're the UK colours! :) Actually we should have said this. I suppose I naively hoped there might be some international co-ordination in the colours ... tsk! I will edit the caption to include this - if we then find out there are 8 million different colour ranges we should maybe include this in the article. Of course, you could always start the Swedish warfarin page off! :) Green, eh? Wow ... Gonegonegone 17:43, 3 Feb 2005 (UTC)
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