From Wikipedia, the free encyclopedia
Talsaclidine (WAL-2014 ) is a non-selective muscarinic acetylcholine receptor agonist which acts as a full agonist at the M1 subtype , and as a partial agonist at the M2 and M3 subtypes .[1] [2] [3] It was under development for the treatment of Alzheimer's disease but showed only modest or poor efficacy in rhesus monkeys and humans , respectively,[4] [3] perhaps due to an array of dose-limiting side effects including increased heart rate and blood pressure , increased salivation , urinary frequency and burning upon urination , increased lacrimation and nasal secretion , abnormal accommodation , heartburn , upset stomach as well as cramps , nausea , vomiting and diarrhea , excessive sweating and palpitations .[5]
See also
References
^ Ensinger HA, Doods HN, Immel-Sehr AR; et al. (1993). "WAL 2014--a muscarinic agonist with preferential neuron-stimulating properties". Life Sciences . 52 (5–6): 473–80. doi :10.1016/0024-3205(93)90304-L . PMID 8441328 . CS1 maint: multiple names: authors list (link )
^ Walland A, Burkard S, Hammer R, Tröger W (1997). "In vivo consequences of M1-receptor activation by talsaclidine". Life Sciences . 60 (13–14): 977–84. doi :10.1016/S0024-3205(97)00037-4 . PMID 9121364 . {{cite journal }}
: CS1 maint: multiple names: authors list (link )
^ a b Wienrich M, Meier D, Ensinger HA; et al. (April 2001). "Pharmacodynamic profile of the M1 agonist talsaclidine in animals and man". Life Sciences . 68 (22–23): 2593–600. doi :10.1016/S0024-3205(01)01057-8 . PMID 11392631 . CS1 maint: multiple names: authors list (link )
^ Terry AV, Buccafusco JJ, Borsini F, Leusch A (July 2002). "Memory-related task performance by aged rhesus monkeys administered the muscarinic M(1)-preferring agonist, talsaclidine". Psychopharmacology . 162 (3): 292–300. doi :10.1007/s00213-002-1105-3 . PMID 12122487 . {{cite journal }}
: CS1 maint: multiple names: authors list (link )
^ Adamus WS, Leonard JP, Tröger W (1995). "Phase I clinical trials with WAL 2014, a new muscarinic agonist for the treatment of Alzheimer's disease". Life Sciences . 56 (11–12): 883–90. doi :10.1016/0024-3205(95)00024-Z . PMID 10188789 . {{cite journal }}
: CS1 maint: multiple names: authors list (link )
Template:Nootropics
mAChRs Tooltip Muscarinic acetylcholine receptors
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