Tandem pore domain potassium channel

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The two-pore-domain potassium channel (not to be confused with the small family of two-pore channels) a family of 15 members form what is known as "leak channels" which possess Goldman-Hodgkin-Katz (open) rectification.[1] These channels are regulated by several mechanisms including oxygen tension, pH, mechanical stretch, and G-proteins .[citation needed] Their name is derived from the fact that the α subunits consist of four transmembrane segments, each containing two pore loops. As such, they structurally correspond to two inward-rectifier α subunits and thus form dimers in the membrane.

Below is a list of the 15 known two-pore-domain human potassium channels:[1]

Gene Channel[2] Family Aliases
KCNK1 K2p1.1 TWIK[3][4] TWIK-1
KCNK2 K2p2.1 TREK[3][4] TREK-1
KCNK3 K2p3.1 TASK[3][4] TASK-1
KCNK4 K2p4.1 TREK[3][4] TRAAK[5]
KCNK5 K2p5.1 TASK[3][4] TASK-2[6]
KCNK6 K2p6.1 TWIK[3][4] TWIK-2
KCNK7 K2p7.1 TWIK[3][4]
KCNK9 K2p9.1 TASK[3][4] TASK-3
KCNK10 K2p10.1 TREK[3][4] TREK-2
KCNK12 K2p12.1 THIK THIK-2
KCNK13 K2p13.1 THIK THIK-1
KCNK15 K2p15.1 TASK[3][4] TASK-5
KCNK16 K2p16.1 TALK[3][4] TALK-1
KCNK17 K2p17.1 TALK[3][4] TALK-2, TASK-4
KCNK18 K2p18.1 TRIK, TRESK[3][4][7][8]

See also[edit]


  1. ^ a b Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. 
  2. ^ Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, and others (2003). "International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels". Pharmacological Reviews 55 (4): 583–6. doi:10.1124/pr.55.4.9. PMID 14657415. 
  3. ^ a b c d e f g h i j k l m Enyedi P, Czirják G (2010). "Molecular background of leak K+ currents: two-pore domain potassium channels". Physiological Reviews 90 (2): 559–605. doi:10.1152/physrev.00029.2009. PMID 20393194. 
  4. ^ a b c d e f g h i j k l m Lotshaw DP (2007). "Biophysical, pharmacological, and functional characteristics of cloned and native mammalian two-pore domain K+ channels". Cell Biochemistry and Biophysics 47 (2): 209–56. doi:10.1007/s12013-007-0007-8. PMID 17652773. 
  5. ^ Fink M, Lesage F, Duprat F, Heurteaux C, Reyes R, Fosset M, Lazdunski M (1998). "A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids". The EMBO Journal 17 (12): 3297–308. doi:10.1093/emboj/17.12.3297. PMC 1170668. PMID 9628867. 
  6. ^ Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nature Reviews Neuroscience 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078. 
  7. ^ Sano Y, Inamura K, Miyake A, Mochizuki S, Kitada C, Yokoi H, Nozawa K, Okada H, Matsushime H, Furuichi K (2003). "A novel two-pore domain K+ channel, TRESK, is localized in the spinal cord". The Journal of Biological Chemistry 278 (30): 27406–12. doi:10.1074/jbc.M206810200. PMID 12754259. 
  8. ^ Czirják G, Tóth ZE, Enyedi P (2004). "The two-pore domain K+ channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurin". The Journal of Biological Chemistry 279 (18): 18550–8. doi:10.1074/jbc.M312229200. PMID 14981085. 

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