Tazobactam

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Not to be confused with Teixobactin.
Tazobactam
Tazobactam structure.svg
Tazobactam ball-and-stick.png
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy
category
  • B
Routes of
administration
Intravenous
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard 100.108.321
Chemical and physical data
Formula C10H12N4O5S
Molar mass 300.289 g/mol
3D model (Jmol)
 NYesY (what is this?)  (verify)

Tazobactam is a pharmaceutical drug that inhibits the action of bacterial β-lactamases, especially those belonging to the SHV-1 and TEM groups. It is commonly used as its sodium salt, tazobactam sodium.

Tazobactam is combined with the extended spectrum β-lactam antibiotic piperacillin in the drug piperacillin/tazobactam, used in infections due Pseudomonas aeruginosa. Tazobactam broadens the spectrum of piperacillin by making it effective against organisms that express β-lactamase and would normally degrade piperacillin.[1]

Tazobactam is a heavily modified penicillin and a sulfone.

Tazobactam was patented in 1982 and came into medical use in 1992.[2]

See also[edit]

References[edit]

  1. ^ Yang Y, Rasmussen BA, Shlaes DM (1999). "Class A beta-lactamases—enzyme-inhibitor interactions and resistance". Pharmacol Ther. 83: 141–151. doi:10.1016/S0163-7258(99)00027-3. 
  2. ^ Fischer, Janos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 490. ISBN 9783527607495.