The song's music video was shot in Los Angeles, and was directed by David LaChapelle on 22 May 2007. The clip features footage of Winehouse making her way through Echo Park and in a dim motel room. The hotel is the Grand Motel at 1479 S La Cienega Blvd, in Los Angeles. She doesn't pay attention to her surroundings as she goes through Echo Park, and in the hotel room there are empty bottles and cigarettes hinting at her real life habits. The video for this song was the second to last filmed prior to Winehouse's death on 23 July 2011.
"Tears Dry on Their Own" became Winehouse's fourth consecutive single to chart inside the top 40 of the UK Singles Chart, when it entered at number 37 on 5 August 2007. It also became her eighth UK R&B top 40 hit. The single spent four weeks at number one on the UK Airplay Chart during August. After the song's physical release, the single climbed into the top 20, peaking at number 16. Therefore, "Tears Dry on Their Own" is Winehouse's second highest-charting single behind "Rehab" and the fourth consecutive top 30 hit from her second album. To date, it has spent 19 non-consecutive weeks on the UK Singles Chart, making it her fourth longest-running hit behind "Rehab" (57 weeks), "Valerie" (39 weeks), and "Back to Black" (34 weeks).
With sales of 84,750, "Tears Dry on Their Own" went on to become the UK's 93rd best-selling single of 2007.
On 31 July, 2011, the song re-entered the UK Singles Chart at 27 after Winehouse's death.