Technetium (99mTc) nofetumomab merpentan

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Technetium (99mTc) nofetumomab merpentan
Technetium-99m nofetumomab merpentan skeletal.svg
Monoclonal antibody
Type Fab fragment
Source Mouse
Clinical data
Trade names Verluma
ATC code
  • none
Pharmacokinetic data
Biological half-life 10.5 hours
Excretion renal (64%)
CAS Number
  • none
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Technetium (99mTc) nofetumomab merpentan (trade name Verluma) is a mouse monoclonal antibody derivative used in the diagnosis of lung cancer,[1] gastrointestinal, breast, ovary, pancreas, kidney, cervix, and bladder carcinoma.[2] The antibody part, nofetumomab, is attached to the chelator merpentan, which links it to the radioisotope technetium-99m (99mTc).[3]


Nofetumomab is an antibody fragment that recognises the pancarcinoma glycoprotein antigen EpCAM.[4] and/or CD20/MS4A1[5]

It is the Fab part of murine MAb NR-LU-10.[6]


The chelator part : merpentan is a phenthioate ligand, 2,3,5,6-tetrafluorophenyl-4,5-bis-5-[1-ethoxyethyl]-thioacetoamidopentanoate.[6]


Phenthioate is an insecticide (Cidial) = O,o-dimethyl-S-(carbethoxy-phenylmethyl)dithiophosphate[7]


  1. ^ Straka, MR; Joyce, JM; Myers, DT (2000). "Tc-99m nofetumomab merpentan complements an equivocal bone scan for detecting skeletal metastatic disease from lung cancer". Clinical nuclear medicine. 25 (1): 54–5. PMID 10634533. doi:10.1097/00003072-200001000-00013. 
  2. ^ Breitz, HB; Tyler, A; Bjorn, MJ; Lesley, T; Weiden, PL (1997). "Clinical experience with Tc-99m nofetumomab merpentan (Verluma) radioimmunoscintigraphy". Clinical nuclear medicine. 22 (9): 615–20. PMID 9298295. doi:10.1097/00003072-199709000-00007. 
  3. ^ WHO Drug Information
  4. ^ Molecular Biology of B Cells. p533
  5. ^ technetium (99mTc) nofetumomab merpentan (TAB-711)
  6. ^ a b Monoclonal Antibody Radionuclide Test Kits
  7. ^ Insecticidal composition and method utilizing phosphoric acid phenylsulphonamide esters US 3934010 A