Tedatioxetine

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Tedatioxetine
Tedatioxetine.svg
Tedatioxetine ball-and-stick model.png
Clinical data
Other namesLu AA24530; Lu-AA-24530
ATC code
  • none
Legal status
Legal status
  • Investigational
Identifiers
CAS Number
PubChem CID
ChemSpider
KEGG
Chemical and physical data
FormulaC18H21NS
Molar mass283.43 g/mol g·mol−1
3D model (JSmol)
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Tedatioxetine (Lu AA24530) is an antidepressant that was discovered by scientists at Lundbeck; in 2007 Lundbeck and Takeda entered into a partnership that included tedatioxetine but was focused on another, more advanced Lundbeck drug candidate, vortioxetine.[1]

Tedatioxetine is reported to act as a triple reuptake inhibitor (5-HT > NE > DA) and 5-HT2A, 5-HT2C, 5-HT3 and α1A-adrenergic receptor antagonist.[2][3][4][5]

As of 2009, it was in phase II clinical trials for major depressive disorder,[5] but there have been no updates since then, and as of August 2013 it was no longer displayed on Lundbeck's product pipeline.[6][7]

On May 10, 2016, all work on tedatioxetine stopped.[8]

A Sino Patent manages to show that there has been interest in this compound outside of Lundbeck: WO 2015090160 

See also[edit]

References[edit]

  1. ^ Daniel Beaulieu for First Word Pharma. September 5th, 2007 Lundbeck, Takeda enter strategic alliance for mood disorder, anxiety drugs
  2. ^ "Patent US20100144788 - 4- [2- (4-methylphenylsulfanyd-phenyl] piperidine with combined serotonin and norepinephrine reuptake inhibition for the treatment of adhd, melancholia, treatment resistant depression or residual symptoms in depression". Retrieved 7 April 2014.
  3. ^ Stephen M. Stahl (19 May 2008). Depression and bipolar disorder: Stahl's essential psychopharmacology. Cambridge University Press. p. 206. ISBN 978-0-521-88663-5. Retrieved 22 November 2011.
  4. ^ Ian P. Stolerman (30 August 2010). Encyclopedia of Psychopharmacology. Springer. p. 105. ISBN 978-3-540-68698-9. Retrieved 22 November 2011.
  5. ^ a b "Lu AA24530 shows positive results in major depressive disorder phase II study - FierceBiotech".
  6. ^ "Pipeline of Lundbeck". Retrieved 25 August 2013.
  7. ^ UK Medicines Information Tedatioxetine entry in UKMI. Page accessed January 20, 2016
  8. ^ "Tedatioxetine - AdisInsight". adisinsight.springer.com. Retrieved 2016-06-09.

External links[edit]