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Combination of
TelmisartanAngiotensin II receptor antagonist
AmlodipineCalcium channel blocker
Clinical data
Trade namesTwynsta, others
License data
Routes of
By mouth
ATC code
Legal status
Legal status
CAS Number

Telmisartan/amlodipine, sold under the brand name Twynsta among others, is a fixed-dose combination medication used to treat high blood pressure.[1] It is a combination of telmisartan, an angiotensin II receptor antagonist, and amlodipine, as the besilate, a calcium channel blocker.[1] It is taken by mouth.[1]

Common side effects include dizziness, swelling, and back pain.[1] Severe side effects may include low blood pressure, kidney problems, electrolyte problems, and a heart attack.[1] Use during pregnancy may harm the baby.[1] Telmisartan works by blocking the effects of angiotensin II while amlodipine works by decreasing calcium ion entry into smooth muscle and heart muscle.[1]

The combination was approved for medical use in the United States in 2009.[1] The combination is on the World Health Organization's List of Essential Medicines.[3][4] It is available as a generic medication.[5]


  1. ^ a b c d e f g h i "DailyMed - Telmisartan and Amlodipine tablet". DailyMed. Retrieved 30 October 2019.
  2. ^ "Twynsta (telmisartan/amlodipine) tablets, for oral use Initial U.S. Approval: 2009". DailyMed. Retrieved 18 March 2023.
  3. ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  4. ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
  5. ^ "Telmisartan and Amlodipine (Professional Patient Advice)". Retrieved 30 October 2019.

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