Temefos

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Temefos
Temefos.svg
Temefos 3D.png
Names
IUPAC name
O,O,O′,O′-Tetramethyl O,O′-sulfanediylbis(1,4-phenylene) diphosphorothioate
Other names
[4-(4-dimethoxyphosphinothioyloxyphenyl)sulfanylphenoxy]-
dimethoxy-sulfanylidene-phosphorane
Identifiers
3383-96-8 YesY
ChEBI CHEBI:38954 YesY
ChEMBL ChEMBL1355821 N
ChemSpider 5199 YesY
Jmol-3D images Image
KEGG D06062 YesY
MeSH Temefos
PubChem 5392
UNII ONP3ME32DL YesY
Properties
C16H20O6P2S3
Molar mass 466.46 g·mol−1
Appearance white, crystalline solid[1]
Density 1.32 g cm−3
Melting point 30 °C (86 °F; 303 K)
Boiling point 120–125[1] °C (248–257 °F; 393–398 K) (decomposes)
insoluble[1]
Vapor pressure 0.00000007 mmHg (20°C)[1]
Hazards
US health exposure limits (NIOSH):
15 mg/m3[1]
TWA 10 mg/m3 (total) TWA 5 mg/m3 (resp)[1]
N.D.[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 N verify (what isYesY/N?)
Infobox references

Temefos or temephos (trade name Abate) is an organophosphate larvicide used to treat water infested with disease-carrying insects[2] including mosquitoes, midges, and black fly larvae.

As with other organophosphates, temephos affects the central nervous system through inhibition of cholinesterase. In larvae, this results in death before reaching the adult stage.

In the developing world where the vector-borne disease dengue fever is endemic, temephos is widely used and applied by both private and public pest control in areas of standing water where the Aedes aegypti mosquito breeds in order to reduce the population of this disease-carrying insect.[3] Temephos is also used in the Guinea worm eradication program to kill water fleas that carry guinea worm larvae.

Resistance to temephos by A. aegypti has been seen in Brazil. The Brazilian Aedes aegypti resistance monitoring program detected temephos resistance in A. aegypti populations from several localities in the country in 1999 (Funasa 2000, Lima et al. 2003). In 1999, mosquitoes from the city of Rio de Janeiro were already resistant to temephos.[4]

References[edit]

  1. ^ a b c d e f g "NIOSH Pocket Guide to Chemical Hazards #0589". National Institute for Occupational Safety and Health (NIOSH). 
  2. ^ Abate Product Information
  3. ^ New York Times article covering its application in Africa
  4. ^ Lima JB, Da-Cunha MP, Da Silva RC et al. (2003). "Resistance of Aedes aegypti to organophosphates in several municipalities in the State of Rio de Janeiro and Espírito Santo, Brazil". Am. J. Trop. Med. Hyg. 68 (3): 329–33. PMID 12685640. 

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