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Phosphatase and tensin homolog
Crystallographic structure of human PTEN. The N-terminal phosphatase domain is colored blue while the C-terminal C2 domain is colored red.[1]
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PTEN ; 10q23del; BZS; CWS1; DEC; GLM2; MHAM; MMAC1; PTEN1; TEP1
External IDs OMIM601728 HomoloGene265 GeneCards: PTEN Gene
EC number,,
Species Human Mouse
Entrez 5728 19211
Ensembl ENSG00000171862 ENSMUSG00000013663
UniProt P60484 O08586
RefSeq (mRNA) NM_000314 NM_008960
RefSeq (protein) NP_000305 NP_032986
Location (UCSC) Chr 10:
87.86 – 87.97 Mb
Chr 19:
32.76 – 32.83 Mb
PubMed search [1] [2]


  1. ^ PDB: 1d5r​; Lee JO, Yang H, Georgescu MM, Di Cristofano A, Maehama T, Shi Y, Dixon JE, Pandolfi P, Pavletich NP (October 1999). "Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association". Cell. 99 (3): 323–34. doi:10.1016/S0092-8674(00)81663-3. PMID 10555148.