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Systematic (IUPAC) name
Clinical data
AHFS/Drugs.com International Drug Names
Routes of
Pharmacokinetic data
Protein binding ~30%
CAS Number 14636-12-5 YesY
ATC code H01BA04 (WHO)
PubChem CID 72081
DrugBank DB02638 YesY
ChemSpider 65067 YesY
UNII 7Z5X49W53P YesY
KEGG D06672 YesY
Chemical data
Formula C52H74N16O15S2
Molar mass 1227.37 g/mol

Terlipressin (trade names Teripress by New Medicon Pharma and Glypressin by Ferring Pharmaceuticals) is an analogue of vasopressin used as a vasoactive drug in the management of low blood pressure. It has been found to be effective when norepinephrine does not help.

Indications for use include norepinephrine-resistant septic shock[1] and hepatorenal syndrome.[2] In addition, it is used to treat bleeding esophageal varices.[3]


Terlipressin is currently not available in the United States,[4] or Canada,[5] but it is available in New Zealand,[6] Australia, much of Europe,[7] India & UAE.


Terlipressin must not be used during pregnancy.

See also[edit]


  1. ^ O'Brien A, Clapp L, Singer M (2002). "Terlipressin for norepinephrine-resistant septic shock". Lancet 359 (9313): 1209–10. doi:10.1016/S0140-6736(02)08225-9. PMID 11955542. 
  2. ^ Uriz J, Ginès P, Cárdenas A, Sort P, Jiménez W, Salmerón J, Bataller R, Mas A, Navasa M, Arroyo V, Rodés J (2000). "Terlipressin plus albumin infusion: an effective and safe therapy of hepatorenal syndrome". J Hepatol 33 (1): 43–8. doi:10.1016/S0168-8278(00)80158-0. PMID 10905585. 
  3. ^ Ioannou G, Doust J, Rockey D (2003). Ioannou GN, ed. "Terlipressin for acute esophageal variceal hemorrhage". Cochrane Database Syst Rev (1): CD002147. doi:10.1002/14651858.CD002147. PMID 12535432. 
  4. ^ "{1} And {2} Report Fast Track Designation For Terlipressin In Type 1 Hepatorenal Syndrome - News, Search Jobs, Events". 
  5. ^ "Drug Product Search". 
  6. ^ http://www.medsafe.govt.nz/profs/datasheet/g/Glypressin01mgmlFerringinj.pdf
  7. ^ http://www.drugs.com/international/terlipressin.html