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562-74-3 YesY
ChEMBL ChEMBL507795 YesY
ChemSpider 10756 YesY
Jmol 3D model Interactive image
MeSH terpinenol-4
PubChem 11230
Molar mass 154.25 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Terpinen-4-ol, also known as 4-Terpineol, is an organic compound in the terpene family. Its molecular formula is C10H18O and its molecular weight is 154.24932 g/mol.

Terpinen-4-ol is used in multiple skin related diseases like blepharitis, rosacea, demodex, meibomian gland dysfunction, chalazia and dry eye. It’s also used in eyelid margin diseases. 4-Terpineol has anti-inflammatory, antibacterial and antifungal effect.

It is considered the primary active ingredient of tea tree oil.[1] It is also the compound of highest concentration in the essential oil of nutmeg.[citation needed]

Terpinen-4-ol occurs in Juniperus communis and is thought to be the reason this wood is highly resistant to rot. Norwegian farmers used to exploit this by making fence poles out of juniper. The concentration is higher in the alpine subspecies of juniper, but occurs in both subspecies.

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  1. ^ Hammer, K. A.; Carson, C. F.; Riley, T. V. (2012). "Effects of Melaleuca alternifolia (Tea Tree) Essential Oil and the Major Monoterpene Component Terpinen-4-ol on the Development of Single- and Multistep Antibiotic Resistance and Antimicrobial Susceptibility". Antimicrobial Agents and Chemotherapy 56 (2): 909–915. doi:10.1128/AAC.05741-11. PMC 3264233. PMID 22083482. 
  1. P. H. Hart, C. Brand, C. F. Carson,T.V. Riley, R. H. Prager and J. J. Finlay-Jones (2000). "Terpinen-4-ol, the main component of the essential oil of Melaleuca alternifolia (tea tree oil), suppresses inflammatory mediator production by activated human monocytes". Inflammation Research 49(11):619-26. PMID 11131302.