Terrie E. Moffitt
Terrie E. Moffitt
|Alma mater||University of North Carolina, University of Southern California, University of California, Los Angeles, University of Wisconsin–Madison|
|Known for||Developmental theory of crime, Gene-environment interaction|
|Awards||Stockholm Prize in Criminology, Klaus J. Jacobs Research Prize|
|Institutions||Duke University, King's College London|
Terrie Edith Moffitt (born March 9, 1955, Nuremberg, Germany) is an American clinical psychologist who is best known for her pioneering research on the development of antisocial behavior and for her collaboration with colleague and partner Avshalom Caspi in research on gene-environment interactions in mental disorders. Moffitt is the Knut Schmidt Nielsen Professor of Psychology & Neuroscience at Duke University (USA) and a Professor of Social behavior and Development in the Medical Research Council's Social, Genetic and Developmental Psychiatry Center at the Institute of Psychiatry, King's College London (UK). She is Associate Director of the Dunedin Longitudinal Study, which follows 1037 people born in 1972-73 in Dunedin, New Zealand. She also launched the Environmental-Risk Longitudinal Twin Study, which follows 1100 British families with twins born in 1994-1995. She has studied the twins from birth to age 12 so far.
Moffitt grew up in North Carolina, United States, and attended the University of North Carolina at Chapel Hill for her undergraduate degree (BA, Psychology 1977). She continued her training in clinical psychology at the University of Southern California (MA, Experimental Animal Behavior 1981; PhD, Clinical Psychology 1984) and completed postdoctoral training at University of California, Los Angeles Neuropsychiatric Institute. In 1985, Moffitt became an assistant professor at the University of Wisconsin–Madison, where she was promoted to full professor in 1995. Moffitt has subsequently served on the faculty at the Institute of Psychiatry, King's College London, and Duke University.
Life and work
Terrie Moffitt studies how genetic and environmental risks work together to shape the course of abnormal human behaviors and psychiatric disorders. Her particular interest is in antisocial and criminal behavior, but she also studies depression, psychosis, addiction, and cognitive aging. She is a licensed clinical psychologist, who completed her clinical hospital training at the UCLA Neuropsychiatric Institute (1984). Her work on the Dunedin Multidisciplinary Health and Development Study in New Zealand has identified patterns of intimate as well as stranger crime, including discoveries about the role of females as initiators of violence. Professor Moffitt is also carrying out an important large-scale follow-up of twins in the UK to investigate biological, psychological, and social influences on development.
Moffitt is best known for her theory of adolescence-limited and life-course-persistent offender antisocial behavior. Moffitt’s theory holds that there are two main types of antisocial offenders in society. Adolescence-Limited offenders exhibit antisocial behavior only during adolescence. Life-Course-Persistent offenders begin to behave antisocially early in childhood and continue this behavior into adulthood. For her studies of crime and human development she was awarded the Stockholm Prize in Criminology.
Gene-Environment Interaction (GxE)
Moffitt is also known for her research on gene-environment interaction (GxE). Her two publications in the journal Science in 2002 and 2003 with her colleague and partner Avshalom Caspi were among the first reports of GxE in humans. The first paper showed that children who carried a polymorphism in the MAOA gene were more vulnerable to developing antisocial behavior following exposure to maltreatment during childhood. The second paper showed that individuals who carried a polymorphism in the serotonin transporter gene (SLC6A4) were more vulnerable to developing depression following exposure to stressful life events. Moffitt and her colleagues have authored a number of articles on theory and methods in GxE research in the fields of psychiatry, psychology, and neuroscience. Moffitt’s research on GxE in the development of antisocial behavior has stimulated a global discussion of the idea of criminal intent and responsibility, as well as raising profound questions about humane strategies for crime prevention among abused children at risk of future violence. The second Science paper, on the interaction of SLC6A4 and life stress has generated enormous controversy, culminating in several meta-analyses published in leading journals in psychiatry and medicine in 2009 and 2011. The most comprehensive meta-analyses do not support the original finding, and the general approach of candidate gene, or candidate gene by environment interaction research in single small studies is no longer widely accepted.
National and International Service Committees
- Nuffield Foundation, Board of Trustees, 2010-2015
- American Society of Criminology, Fellows Committee, 2010 
- The Health and Retirement Study, Data Monitoring Board, 2009 
- Stockholm Criminology Prize Jury, 2007-2012 
- National Academy of Sciences, Panel on Understanding and Controlling the Demand for Illegal Drugs, 2007-2010 
- National Academy of Sciences, Advisory Committee on Law and Justice, 2005-2011 
- Academia Europaea, Behavioural Sciences section committee, 2008-2010 
- American Psychiatric Association WHO-NIMH committee to review research on DSM-V externalizing disorders, 2004-2007 
- Faculty 1000 of Medicine, 2005-2007 
- UK Department of Trade and Industry, Office of Science and Innovation, Foresight Project on Mental Capital, 2006 
- Institute Fellow, University of Cambridge Institute of Criminology, 2004-2007 
- National Academy of Sciences, Committee on Improving Research Data on Firearms, 2001-2004 
- Medical Research Council Advisory Board member, 2001–2003, College of Experts, 2005-2009 
- APA Working Group on Genetics Research, 2002-2003 
- Nuffield Council on Bioethics Working Party on Ethics of Research in Genes and Behaviour, UK, 2000-2003 
- Jacobs Foundation Young Investigator Awards Committee, Switzerland, 1998 - 2001 
- National Science Foundation National Consortium on Violence Research (NCOVR) Steering Committee, 1995–1998, 2002-2003 
In 2006, she was awarded the Society of Clinical Child and Adolescent Psychology Distinguished Career Award. 
- Average citations per item = 125, Citations in 2013 >3800
- H-index = 100, 15 January 2014,
- Web of Knowledge Researcher ID: D-5295-2011
- Moffitt TE. Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. Psychol Rev. Oct 1993;100(4):674-701.
- Moffitt TE. The neuropsychology of conduct disorder. Dev Psychopathol. Win-Spr 1993;5(1-2):135-151.
- Moffitt TE, Caspi A, Dickson N, Silva P, Stanton W. Childhood-onset versus adolescent-onset antisocial conduct problems in males: Natural history from ages 3 to 18 years. Dev Psychopathol. Spr 1996;8(2):399-424.
- Caspi A, McClay J, Moffitt TE, et al. Role of genotype in the cycle of violence in maltreated children. Science. Aug 2002;297(5582):851-854 (PDF).
- Caspi A, Sugden K, Moffitt TE, et al. Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science. Jul 2003;301(5631):386-389 (PDF).
- Moffitt TE. The new look of behavioral genetics in developmental psychopathology: Gene-environment interplay in antisocial behaviors. Psychol Bull. Jul 2005;131(4):533-554 (PDF[permanent dead link]).
- Caspi A, Moffitt TE, Cannon M, et al. Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: Longitudinal evidence of a gene X environment interaction. Biol Psychiatry. May 2005;57(10):1117-1127 (PDF).
- Moffitt TE, Caspi A, Rutter M. Strategy for investigating interactions between measured genes and measured environments. Arch Gen Psychiatry. May 2005;62(5):473-481 (PDF[permanent dead link]).
- Caspi A, Moffitt TE. Gene-environment interactions in psychiatry: joining forces with neuroscience. Nat Rev Neurosci. Jul 2006;7(7):583-590 (PDF[permanent dead link]).
- Caspi A, Williams B, Kim-Cohen J, et al. Moderation of breastfeeding effects on the IQ by genetic variation in fatty acid metabolism. Proc Natl Acad Sci U S A. Nov 20 2007;104(47):18860-18865.
- Polanczyk G, Caspi A, Williams B, et al. Protective Effect of CRHR1 Gene Variants on the Development of Adult Depression Following Childhood Maltreatment Replication and Extension. Arch Gen Psychiatry. Sep 2009;66(9):978-985.
- Caspi A, Hariri AR, Holmes A, Uher R, Moffitt TE. Genetic Sensitivity to the Environment: The Case of the Serotonin Transporter Gene and Its Implications for Studying Complex Diseases and Traits. Am J Psychiatry. May 2010;167(5):509-527.
- Moffitt TE, Arseneault L, Belsky D, et al. A gradient of childhood self-control predicts health, wealth, and public safety. Proc Natl Acad Sci U S A. Feb 15 2011;108(7):2693-2698.
- "Adolescence-limited and life-course-persistent antisocial behavior: A developmental taxonomy". Archived from the original on May 27, 2015. Retrieved March 17, 2012.
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- "Role of Genotype in the Cycle of Violence in Maltreated Children". Sciencemag.org. 2002-08-02. Retrieved 2012-07-31.
- "Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene - Caspi et al. 301 (5631): 386 - Science Signaling". Stke.sciencemag.org. 2003-07-22. doi:10.1126/science.1083968. Retrieved 2012-07-31.
- "JAMA Network | Archives of General Psychiatry | Strategy for Investigating Interactions Between Measured Genes and Measured Environments". Archpsyc.ama-assn.org. Retrieved 2012-07-31.
- "The New Look of Behavioral Genetics in Developmental Psychopathology: Gene-Environment Interplay in Antisocial Behaviors". Psycnet.apa.org. doi:10.1037/0033-2909.131.4.533. Retrieved 2012-07-31.
- M Munafò (2011-02-11). "GL.05 Controversies in gene–environment interaction research: why all the fuss? - Munafò 82 (8): e2 - Journal of Neurology, Neurosurgery & Psychiatry". Jnnp.bmj.com. Retrieved 2012-07-31.
- Duncan LE, Keller MC (October 2011). "A critical review of the first 10 years of candidate gene-by-environment interaction research in psychiatry". The American Journal of Psychiatry. 168 (10): 1041–9. doi:10.1176/appi.ajp.2011.11020191. PMC 3222234. PMID 21890791.
- Culverhouse, R. C.; Saccone, N. L.; Horton, A. C.; Ma, Y.; Anstey, K. J.; Banaschewski, T.; Burmeister, M.; Cohen-Woods, S.; Etain, B. (2017-04-04). "Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression". Molecular Psychiatry. doi:10.1038/mp.2017.44. ISSN 1476-5578.
- Hewitt, John K. (2011). "Editorial Policy on Candidate Gene Association and Candidate Gene-by-Environment Interaction Studies of Complex Traits". Behavior Genetics. 42 (1): 1–2. doi:10.1007/s10519-011-9504-z. ISSN 0001-8244.
- Johnson, Emma C.; Border, Richard; Melroy-Greif, Whitney E.; de Leeuw, Christiaan A.; Ehringer, Marissa A.; Keller, Matthew C. (2017). "No Evidence That Schizophrenia Candidate Genes Are More Associated With Schizophrenia Than Noncandidate Genes". Biological Psychiatry. 82 (10): 702–708. doi:10.1016/j.biopsych.2017.06.033. ISSN 0006-3223.
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- "Moderation of breastfeeding effects on the IQ by genetic variation in fatty acid metabolism". Proceedings of the National Academy of Sciences. 104: 18860–18865. doi:10.1073/pnas.0704292104. PMC 2141867. Retrieved 2013-10-30.
- "JAMA Network | Archives of General Psychiatry | Protective Effect of CRHR1 Gene Variants on the Development of Adult Depression Following Childhood MaltreatmentReplication and ExtensionMaltreatment/CRHR1 Variant Effects on Depression". Archpsyc.ama-assn.org. Retrieved 2012-07-31.
- Caspi, A; Hariri, A. R.; Holmes, A; Uher, R; Moffitt, T. E. (2013-03-25). "Genetic Sensitivity to the Environment: The Case of the Serotonin Transporter Gene and Its Implications for Studying Complex Diseases and Traits". American Journal of Psychiatry. 167 (5): 509–527. doi:10.1176/appi.ajp.2010.09101452. PMC 2943341. PMID 20231323.
- Angela L. Duckworth. "A gradient of childhood self-control predicts health, wealth, and public safety". Proceedings of the National Academy of Sciences. 108: 2693–2698. doi:10.1073/pnas.1010076108. PMC 3041102. Retrieved 2013-10-30.