|3D model (Jmol)||Interactive image|
|E number||E319 (antioxidants, ...)|
|Molar mass||166.22 g·mol−1|
|Melting point||127 to 129 °C (261 to 264 °F; 400 to 402 K)|
|Boiling point||273 °C (523 °F; 546 K)|
|Safety data sheet||External MSDS|
|S-phrases||S26 S27 S28|
|Flash point||171 °C (340 °F; 444 K)|
|Butylated hydroxyanisole (BHA)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
In foods, TBHQ is used as a preservative for unsaturated vegetable oils and many edible animal fats. It does not cause discoloration even in the presence of iron, and does not change flavor or odor of the material to which it is added. It can be combined with other preservatives such as butylated hydroxyanisole (BHA). As a food additive, its E number is E319. It is added to a wide range of foods, with the highest limit (1 gram/kg) permitted for frozen fish and fish products. Its primary advantage is extending storage life.
In perfumery, it is used as a fixative to lower the evaporation rate and improve stability.
It is used as a corrosion inhibitor in biodiesel.
Safety and regulation
Both the European Food Safety Authority (EFSA) and the United States Food and Drug Administration (FDA) have evaluated TBHQ and determined that it is safe to consume at the concentration allowed in foods. The FDA sets an upper limit of 0.02% of the oil or fat content in foods. At very high doses, it has some negative health effects on lab animals, such as producing precursors to stomach tumors and damage to DNA. A number of studies have shown that prolonged exposure to very high doses of TBHQ may be carcinogenic, especially for stomach tumors. Other studies, however, have shown opposite effects including inhibition against HCA-induced carcinogenesis (by depression of metabolic activation) for TBHQ and other phenolic antioxidants (TBHQ was one of several, and not the most potent). The EFSA considers TBHQ to be noncarcinogenic. A 1986 review of scientific literature concerning the toxicity of TBHQ determined that a wide margin of safety exists between the levels of intake by humans and the doses that produce adverse effects in animal studies. Michigan State University scientists are studying a possible link between TBHQ and food allergies 
- Fats and oils: formulating and processing for applications, Richard D. O'Brien, page 168
- Almeida, E.S., et al (2011). Behaviour of the antioxidant tert-butylhydroquinone on the storage stability and corrosive character of biodiesel. FUEL 90 (11): 3480-3484. doi:10.1016/j.fuel.2011.06.056
- "Food Additive Status List". U.S. Food and Drug Administration. Retrieved June 11, 2016.
- "Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to tertiary-Butylhydroquinone (TBHQ)". European Food Safety Authority, 12 July 2004
- 21 C.F.R. § 172.185
- Tert-Butylhydroquinone - safety summary from The International Programme on Chemical Safety
- Gharavi N, El-Kadi A (2005). "tert-Butylhydroquinone is a novel aryl hydrocarbon receptor ligand". Drug Metab Dispos. 33 (3): 365–72. doi:10.1124/dmd.104.002253. PMID 15608132.
- Hirose, Masao; Yada, Hideaki; Hakoi, Kazuo; Takahashi, Satoru; Ito, Nobuyuki; et al. "Modification of carcinogenesis by -tocopherol, t-butylhydro-quinone, propyl gallate and butylated hydroxytoluene in a rat multi-organ carcinogenesis model". Carcinogenesis. Oxford University Press. 14 (1): 2359–2364. doi:10.1093/carcin/14.11.2359. PMID 8242867. Retrieved 2 February 2010.
- Hirose M, Takahashi S, Ogawa K, Futakuchi M, Shirai T, Shibutani M, Uneyama C, Toyoda K, Iwata H (1999). "Chemoprevention of heterocyclic amine-induced carcinogenesis by phenolic compounds in rats". Cancer Lett. 143 (2): 173–8. doi:10.1016/S0304-3835(99)00120-2. PMID 10503899.
- Vanesch, G (1986). "Toxicology of tert-butylhydroquinone (TBHQ)". Food and Chemical Toxicology. 24 (10–11): 1063–5. doi:10.1016/0278-6915(86)90289-9. PMID 3542758.