Testicular receptor 2

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Nuclear receptor subfamily 2, group C, member 1
Symbols NR2C1 ; TR2
External IDs OMIM601529 MGI1352465 HomoloGene55731 IUPHAR: 613 GeneCards: NR2C1 Gene
RNA expression pattern
PBB GE NR2C1 210530 s at tn.png
PBB GE NR2C1 210531 at tn.png
PBB GE NR2C1 204791 at tn.png
More reference expression data
Species Human Mouse
Entrez 7181 22025
Ensembl ENSG00000120798 ENSMUSG00000005897
UniProt P13056 Q505F1
RefSeq (mRNA) NM_001032287 NM_011629
RefSeq (protein) NP_001027458 NP_035759
Location (UCSC) Chr 12:
95.02 – 95.07 Mb
Chr 10:
94.15 – 94.2 Mb
PubMed search [1] [2]

The testicular receptor 2 (TR2) also known as NR2C1 (nuclear receptor subfamily 2, group C, member 1) is protein that in humans is encoded by the NR2C1 gene.[1][2] TR2 is a member of the nuclear receptor family of transcription factors.


Testicular receptor 2 has been shown to interact with:

See also[edit]


  1. ^ "Entrez Gene: NR2C1 nuclear receptor subfamily 2, group C, member 1". 
  2. ^ Chang C, Kokontis J, Acakpo-Satchivi L, Liao S, Takeda H, Chang Y (Dec 1989). "Molecular cloning of new human TR2 receptors: a class of steroid receptor with multiple ligand-binding domains". Biochemical and Biophysical Research Communications 165 (2): 735–41. doi:10.1016/S0006-291X(89)80028-2. PMID 2597158. 
  3. ^ Mu X, Chang C (Oct 2003). "TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC-3". The Prostate 57 (2): 129–33. doi:10.1002/pros.10282. PMID 12949936. 
  4. ^ Hu YC, Shyr CR, Che W, Mu XM, Kim E, Chang C (Sep 2002). "Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor". The Journal of Biological Chemistry 277 (37): 33571–9. doi:10.1074/jbc.M203531200. PMID 12093804. 
  5. ^ Li G, Franco PJ, Wei LN (Oct 2003). "Identification of histone deacetylase-3 domains that interact with the orphan nuclear receptor TR2". Biochemical and Biophysical Research Communications 310 (2): 384–90. doi:10.1016/j.bbrc.2003.08.145. PMID 14521922. 
  6. ^ a b Franco PJ, Li G, Wei LN (Aug 2003). "Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase". Molecular and Cellular Endocrinology 206 (1-2): 1–12. doi:10.1016/S0303-7207(03)00254-5. PMID 12943985. 
  7. ^ a b Franco PJ, Farooqui M, Seto E, Wei LN (Aug 2001). "The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases". Molecular Endocrinology 15 (8): 1318–28. doi:10.1210/mend.15.8.0682. PMID 11463856. 

Further reading[edit]