Testicular receptor 2

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AliasesNR2C1, TR2, Testicular receptor 2, nuclear receptor subfamily 2 group C member 1
External IDsMGI: 1352465 HomoloGene: 55731 GeneCards: NR2C1
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for NR2C1
Genomic location for NR2C1
Band12q22Start95,020,229 bp[1]
End95,073,628 bp[1]
RNA expression pattern
PBB GE NR2C1 210530 s at fs.png

PBB GE NR2C1 204791 at fs.png

PBB GE NR2C1 210531 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 12: 95.02 – 95.07 MbChr 10: 94.15 – 94.2 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

The testicular receptor 2 (TR2) also known as NR2C1 (nuclear receptor subfamily 2, group C, member 1) is protein that in humans is encoded by the NR2C1 gene.[5][6] TR2 is a member of the nuclear receptor family of transcription factors.


Testicular receptor 2 has been shown to interact with:

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000120798 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005897 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ "Entrez Gene: NR2C1 nuclear receptor subfamily 2, group C, member 1".
  6. ^ Chang C, Kokontis J, Acakpo-Satchivi L, Liao S, Takeda H, Chang Y (Dec 1989). "Molecular cloning of new human TR2 receptors: a class of steroid receptor with multiple ligand-binding domains". Biochemical and Biophysical Research Communications. 165 (2): 735–41. doi:10.1016/S0006-291X(89)80028-2. PMID 2597158.
  7. ^ Mu X, Chang C (Oct 2003). "TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC-3". The Prostate. 57 (2): 129–33. doi:10.1002/pros.10282. PMID 12949936.
  8. ^ Hu YC, Shyr CR, Che W, Mu XM, Kim E, Chang C (Sep 2002). "Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor". The Journal of Biological Chemistry. 277 (37): 33571–9. doi:10.1074/jbc.M203531200. PMID 12093804.
  9. ^ Li G, Franco PJ, Wei LN (Oct 2003). "Identification of histone deacetylase-3 domains that interact with the orphan nuclear receptor TR2". Biochemical and Biophysical Research Communications. 310 (2): 384–90. doi:10.1016/j.bbrc.2003.08.145. PMID 14521922.
  10. ^ a b Franco PJ, Li G, Wei LN (Aug 2003). "Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase". Molecular and Cellular Endocrinology. 206 (1–2): 1–12. doi:10.1016/S0303-7207(03)00254-5. PMID 12943985.
  11. ^ a b Franco PJ, Farooqui M, Seto E, Wei LN (Aug 2001). "The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases". Molecular Endocrinology. 15 (8): 1318–28. doi:10.1210/mend.15.8.0682. PMID 11463856.

Further reading[edit]