Testicular receptor 4

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Nuclear receptor subfamily 2, group C, member 2
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols NR2C2 ; TAK1; TR4
External IDs OMIM601426 MGI1352466 HomoloGene2475 IUPHAR: 614 ChEMBL: 5716 GeneCards: NR2C2 Gene
RNA expression pattern
PBB GE NR2C2 206038 s at tn.png
More reference expression data
Species Human Mouse
Entrez 7182 22026
Ensembl ENSG00000177463 ENSMUSG00000005893
UniProt P49116 P49117
RefSeq (mRNA) NM_001291694 NM_011630
RefSeq (protein) NP_001278623 NP_035760
Location (UCSC) Chr 3:
14.95 – 15.05 Mb
Chr 6:
92.09 – 92.17 Mb
PubMed search [1] [2]

Testicular receptor 4 also known as NR2C2 (nuclear receptor subfamily 2, group C, member 2) is a protein that in humans is encoded by the NR2C2 gene.[1][2][3]

The testicular receptor 4 is a member of the nuclear receptor family of transcription factors.


Testicular receptor 4 has been shown to interact with

See also[edit]


  1. ^ "Entrez Gene: NR2C2". 
  2. ^ Chang C, Da Silva SL, Ideta R, Lee Y, Yeh S, Burbach JP (June 1994). "Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily". Proc. Natl. Acad. Sci. U.S.A. 91 (13): 6040–4. doi:10.1073/pnas.91.13.6040. PMC 44133. PMID 8016112. 
  3. ^ Yoshikawa T, DuPont BR, Leach RJ, Detera-Wadleigh SD (July 1996). "New variants of the human and rat nuclear hormone receptor, TR4: expression and chromosomal localization of the human gene". Genomics 35 (2): 361–6. doi:10.1006/geno.1996.0368. PMID 8661150. 
  4. ^ Lee YF, Shyr CR, Thin TH, Lin WJ, Chang C (December 1999). "Convergence of two repressors through heterodimer formation of androgen receptor and testicular orphan receptor-4: a unique signaling pathway in the steroid receptor superfamily". Proc. Natl. Acad. Sci. U.S.A. 96 (26): 14724–9. doi:10.1073/pnas.96.26.14724. PMC 24715. PMID 10611280. 
  5. ^ Shyr CR, Hu YC, Kim E, Chang C (April 2002). "Modulation of estrogen receptor-mediated transactivation by orphan receptor TR4 in MCF-7 cells". J. Biol. Chem. 277 (17): 14622–8. doi:10.1074/jbc.M110051200. PMID 11844790. 
  6. ^ Lin WJ, Li J, Lee YF, Yeh SD, Altuwaijri S, Ou JH, Chang C (March 2003). "Suppression of hepatitis B virus core promoter by the nuclear orphan receptor TR4". J. Biol. Chem. 278 (11): 9353–60. doi:10.1074/jbc.M205944200. PMID 12522137. 

Further reading[edit]

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