Testicular receptor 4

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Available structures
PDB Ortholog search: PDBe RCSB
Aliases NR2C2, TAK1, TR4, Testicular receptor 4, nuclear receptor subfamily 2 group C member 2
External IDs MGI: 1352466 HomoloGene: 2475 GeneCards: 7182
Targeted by Drug
Vitamin A, all-trans-retinoic acid[1]
RNA expression pattern
PBB GE NR2C2 206038 s at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 3: 14.95 – 15.05 Mb Chr 6: 92.09 – 92.17 Mb
PubMed search [2] [3]
View/Edit Human View/Edit Mouse

Testicular receptor 4 also known as NR2C2 (nuclear receptor subfamily 2, group C, member 2) is a protein that in humans is encoded by the NR2C2 gene.[4][5][6]

The testicular receptor 4 is a member of the nuclear receptor family of transcription factors.


Testicular receptor 4 has been shown to interact with

See also[edit]


  1. ^ "Drugs that physically interact with Nuclear receptor subfamily 2 group C member 2 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ "Entrez Gene: NR2C2". 
  5. ^ Chang C, Da Silva SL, Ideta R, Lee Y, Yeh S, Burbach JP (Jun 1994). "Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily". Proceedings of the National Academy of Sciences of the United States of America. 91 (13): 6040–4. doi:10.1073/pnas.91.13.6040. PMC 44133free to read. PMID 8016112. 
  6. ^ Yoshikawa T, DuPont BR, Leach RJ, Detera-Wadleigh SD (Jul 1996). "New variants of the human and rat nuclear hormone receptor, TR4: expression and chromosomal localization of the human gene". Genomics. 35 (2): 361–6. doi:10.1006/geno.1996.0368. PMID 8661150. 
  7. ^ Lee YF, Shyr CR, Thin TH, Lin WJ, Chang C (Dec 1999). "Convergence of two repressors through heterodimer formation of androgen receptor and testicular orphan receptor-4: a unique signaling pathway in the steroid receptor superfamily". Proceedings of the National Academy of Sciences of the United States of America. 96 (26): 14724–9. doi:10.1073/pnas.96.26.14724. PMC 24715free to read. PMID 10611280. 
  8. ^ Shyr CR, Hu YC, Kim E, Chang C (Apr 2002). "Modulation of estrogen receptor-mediated transactivation by orphan receptor TR4 in MCF-7 cells". The Journal of Biological Chemistry. 277 (17): 14622–8. doi:10.1074/jbc.M110051200. PMID 11844790. 
  9. ^ Lin WJ, Li J, Lee YF, Yeh SD, Altuwaijri S, Ou JH, Chang C (Mar 2003). "Suppression of hepatitis B virus core promoter by the nuclear orphan receptor TR4". The Journal of Biological Chemistry. 278 (11): 9353–60. doi:10.1074/jbc.M205944200. PMID 12522137. 

Further reading[edit]

External links[edit]