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Tetrachlorodecaoxide (TCDO) is a chlorite-containing, immunomodulatory, macrophage-activating drug whose chemical formula is Cl4H2O11.[1][2][3][4] The drug WF10 (Macrokine, Immunokine) is an aqueous solution of tetrachlorodecaoxide designed for intravenous injection.[3] Tetrachlorodecaoxide and WF10 were originally developed by Oxo Chemie.[5]

Tetrachlorodecaoxide / WF10 is used in the management of radiation cystitis,[6] is effective in the treatment of diabetic foot ulcers,[7] and is used in wound healing, where the mechanism of action is activation of the macrophage system, and increasing the partial pressure of oxygen in the wound.[8]


  1. ^ "Tetrachlorodecaoxide - Cl4H2O11-4". Pubchem.ncbi.nlm.mih.gov. Retrieved 2016-12-20.
  2. ^ "92047-76-2, molecular oxygen tetrachlorite hydrate, CAS No 92047-76-2 molecular oxygen tetrachlorite hydrate". Chemnet.com. Retrieved 2016-12-20.
  3. ^ a b "WF10". Drugprofiles.informa.com. Retrieved 2016-12-20.
  4. ^ Maraprygsavan, Paiboon; Mongkolsuk, Jarasporn; Arnhold, Juergen; Kuehne, Friedrich-Wilhelm (2016). "The chlorite-based drug WF10 constantly reduces hemoglobin A1c values and improves glucose control in diabetes patients with severe foot syndrome". Journal of Clinical & Translational Endocrinology. 4: 53–8. doi:10.1016/j.jcte.2016.05.001.
  5. ^ "About Us - Immunokine® - WF10 - OXO Chemie (Thailand) Co., Ltd". Oxothai.com. Retrieved 2016-12-20.
  6. ^ Smit, Shaun G.; Heyns, Chris F. (2010). "Management of radiation cystitis". Nature Reviews Urology. 7 (4): 206–14. doi:10.1038/nrurol.2010.23. PMID 20212517.
  7. ^ Yingsakmongkol, N. (2013). "Clinical outcomes of WF10 adjunct to standard treatment of diabetic foot ulcers". Journal of Wound Care. 22 (3): 130–2, 134–6. doi:10.12968/jowc.2013.22.3.130. PMID 23665731.
  8. ^ Parikh, Romil; Bakhshi, Girish; Naik, Madhushree; Gaikwad, Bhargav; Jadhav, Kavita; Tayade, Mukund (2016). "The Efficacy and Safety of Tetrachlorodecaoxide in Comparison with Super-oxidised Solution in Wound Healing". Archives of Plastic Surgery. 43 (5): 395–401. doi:10.5999/aps.2016.43.5.395. PMC 5040840. PMID 27689045.

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