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A tetrad is a "group of four". It may refer to:
- Tetrad (chromosomal formation)
- Tetrad (genetics), the four spores of a yeast
- Tetrad (general relativity), a mathematical frame of reference in general relativity
- Tetrad (index notation), a concept in differential geometry
- Tetrad (music), a set of four notes
- Tetrad (symbol) or tetractys
- Tetrad (unit of area)
- Tetrad, a group of four haploid and immature pollen grains in tetrahedral fashion produced by meiotic microsporogenesis
- Tetrad (astronomy), an occurrence of 4 total lunar eclipses in a row with intervals of 6 lunations (semester).
- Tetrad (computing), a 4-bit group
- Celsus tetrad, the four cardinal signs of inflammation
- Dark tetrad, group of four undesirable personality traits
- Tetrad of media effects, a pedagogical tool
- Tetromino, a shape composed of four squares
- Tetrad, an open-source software package for causal discovery and statistical analysis
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