tetramethyl orthosilicate; methyl silicate; silicic acid, tetramethyl ester; silicon methoxide; TMOS
3D model (Jmol)
|Melting point||4 to 5 °C (39 to 41 °F; 277 to 278 K)|
|Boiling point||121 to 122 °C (250 to 252 °F; 394 to 395 K)|
|Vapor pressure||12 mmHg (25°C)|
|Flash point||96 °C; 205 °F; 369 K |
|US health exposure limits (NIOSH):|
|TWA 1 ppm (6 mg/m3)|
IDLH (Immediate danger)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
Tetramethyl orthosilicate is the chemical compound with the formula Si(OCH3)4. This molecule consists of four methyl groups attached to the hypothetical anion SiO44−. The basic properties are similar to the more popular tetraethyl orthosilicate, which is usually preferred because the product of hydrolysis, ethanol, is less toxic than methanol.
Tetramethyl orthosilicate hydrolyzes to SiO2:
The hydrolysis of Si(OCH3)4 produces insoluble SiO2 and CH3OH (methanol). Even at low concentrations inhalation causes lung lesions, and at slightly higher concentrations eye contact with the vapor causes blindness. Worse, at low concentrations (200ppm/15min) the damage is often insidious, with onset of symptoms hours after exposure. The mode of action is the precipitation of silica in the eyes and/or lungs. Contrary to common information, including several erroneous MSDS sheets, the methanol produced is relatively innocuous. The mechanisms of methanol toxicity are well established, methanol causes blindness via conversion to toxic formaldehyde in the liver; methanol splashes to the eye cause only moderate and reversible eye irritation.
Tetraethyl orthosilicate is safer for two reasons. 1) It is considerably less volatile. 2) It is hydrolyzed more slowly by the water in the lungs and on the eyes (due to steric bulk).
- "NIOSH Pocket Guide to Chemical Hazards #0428". National Institute for Occupational Safety and Health (NIOSH).
- Sakurai, H. "Silicon(IV) Methoxide" in Encyclopedia of Reagents for Organic Synthesis 2001 John Wiley & Sons. doi:10.1002/047084289X.rs012
- "Tetramethyl silicate". National Library of Medicine - Hazardous Substances Data Bank. National Library of Medicine. Retrieved 11 February 2013.
- "Methanol". Hazardous Substances Data Bank - National Library of Medicine. National Library of Medicine. Retrieved 11 February 2013.