SH 357 begins in southwestern Corpus Christi at FM 665 and heads towards the southeast along Saratoga Boulevard. As it heads to the southeast, it passes under SH 286 (Crosstown Expressway) at a diamond interchange. As it heads southeast from the interchange, the highway intersects FM 43 (Weber Road) and FM 2444 (Staples Street). Saratoga Boulevard comes to an end at an intersection with Rodd Field Road. SH 357 follows Rodd Field Road from this intersection to the northeast to its eastern terminus at SH 358 (South Padre Island Drive).