Thapsia, commonly known as the deadly carrots, is a small genus of poisonous plants in the family Apiaceae. Their center of diversity is around the western Mediterranean, extending into the Atlantic coasts of Portugal and Morocco. Some species are used in traditional medicine.
Species of Thapsia are herbaceous perennials, growing 50 to 200 cm high. The inflorescences are large, regularly distributed umbels. The seeds have four wings, and are the main characteristic of the genus, which is distributed in the Mediterranean, on the Iberian peninsula, and North Africa.
The generic name Thapsia is derived from the Ancient Greek name θαψία (thapsía) for the members of the genus. The Greeks believe it to have originated from ancient Thapsos in Sicily. It has a long history of being used in ancient traditional medicine. Algerians used it as a pain-reliever though they recognized that the plant was deadly to camels. The Greek colony of Cyrene exported a medicinal plant known as silphion, used as a purgative and emetic. Although its exact identity remains contentious today, some historians believe that the plant may have been Thapsia garganica.
The chemical compound thapsigargin has been isolated from Thapsia garganica. A synthetic prodrug of thapsigargin called "G-202" is in preliminary clinical trials for cancer treatment. The active constituent kills tumor cells by destroying their calcium balance. A biotech company called GenSpera, Inc. in San Antonio, TX is studying methods of delivering thapsigargin directly to cancer cells, avoiding damage to other cells in the body of the patient.
- Thapsia cinerea A.Pujadas
- Thapsia decussata Lag.
- Thapsia garganica L.
- Thapsia gymnesica Rosselló & A.Pujadas
- Thapsia platycarpa Pomel
- Thapsia minor Hoffmans & Link
- Thapsia nitida Lacaita
- Thapsia villosa L.
- Thapsia transtagana Brot.
- M. Seoane (1831). Neuman & Baretti's Dictionary of the Spanish and English Languages. William Clowes.
- S. Iadjel; A. Zellagui & N. Gherraf (2011). "Reinvestigation of essential oil content of Thapsia garganica grown in the east of Algeria" (PDF). Revue des Sciences fondamentales et appliquées. 2: 30–34.
- S. Castroviejo; et al., eds. (2003). Flora Iberica. Volume X: Araliaceae-Umbelliferae (PDF). Real Jardín Botánico. pp. 401–410. ISBN 8400081501.
- M. Grieve. "Thapsia". Botanical.com. Retrieved August 26, 2012.
- "Thapsigargin prodrug G-202". NCI Cancer Dictionary.
- Kristen Philipkoski. "Scientists Transform Deadly Plant Into Cancer Killing Smart Bomb". Gizmodo.com.
- Pujadas-Salva, A. J.; Plaza-Arregui, L. (2003). "Studies on Thapsia (Apiaceae) from north-western Africa: A forgotten and a new species" (PDF). Botanical Journal of the Linnean Society. 143 (4): 433. doi:10.1111/j.1095-8339.2003.00233.x.
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