The video for the single was shot in May 2010 during the band's visit to Los Angeles, California, while recording their second album. Directed by Frank Borin, it takes its inspiration from the popular US TV series Entourage. The video shows the band turn up to a party in a nightclub in downtown L.A., where they also perform their song on a revolving stage.
"The Club Is Alive" debuted on the Irish Singles Chart on 9 July 2010 at number four where it remained for two consecutive weeks, marking the band's third top five hit in the country. On 11 July 2010, the song debuted on the UK Singles Chart at number one. It became their third number one single, selling 84,283 copies in its first week. Despite the initial success of the song, it dropped six places to number seven the following week and then a further two places to number nine on 25 July 2010. On 1 August 2010, the song dropped a further seven places to number sixteen.