In 2009, Winfrey offered to produce a syndicated series featuring Mehmet Oz through her company, Harpo Productions.The Dr. Oz Show debuted September 14, 2009. It received Daytime Emmy nominations for Outstanding Talk Show Informative and Outstanding Talk Show Informative Host in 2010, winning the latter.
According to The New Yorker, the series is "among the most highly rated daily television programs" in the United States. It consistently scores ratings with daytime television's primary demographic of women from ages 25-54. During the 2016 season, The Dr. Oz Show averaged a 1.4 Nielsen household rating in live-plus-same day numbers. It had a 1.2 Nielsen household rating in 2017 and a 1.1 rating during the 2018 season.
Over the course of its run, The Dr. Oz Show and other similar medical talk shows have been criticized for featuring subject matter that is not supported by published studies. The British Medical Journal found that more than half of the recommendations on these shows contradicted medical research. Producers for the show have stated that the series gives viewers "the most information and the greatest number of tools they can use to make their own choices."