Breed signed to UMZ Entertainment after leaving Fharmacy Recordings. UMZ was founded by Alex Abbiss as a subsidiary of Psychopathic Records, a label founded by Abbiss and Insane Clown Posse. Abbiss wanted to release music intended for a wider audience than ICP's Juggalo fanbase. Regarding Breed, ICP member and label chairman Joseph Bruce stated, "It’s just a business relationship that turned friends. We’re not doing anything with him in the future that we know of as far as tours or anything like that. He’s just doing his thing. His record is a great record."
Breed recorded The New Prescription with production by Psychopathic artist Esham, Psychopathic-affiliated rapper Lavel, and non-affiliated producers Ess Man and G. Piece. The album's songs were engineered, mixed, and arranged by Psychopathic producers Fritz the Cat, J. Hicks and Esham. "Gotta Go" featured vocals by singer Tobi, while "Roll" featured a guest rap verse by Esham.