The lyrics of the song deal with the use of club drugs such as MDMA and Ketamine in nightclubs and parties. The song deals with the effects of such drugs on the human body through the eyes of a user, who asks, "Is it so wrong, to want rewarding?/To want more than is given to you?".
A video for the song was released on 5 December 2006, and was directed by Walter Stern, also known for directing videos by Massive Attack, The Prodigy and most notably The Verve's "Bitter Sweet Symphony". In the video, all members of Bloc Party are at a nightclub (which, in reality, is Café 1001 in London). It follows them throughout the night even though they do not appear to be doing much. Okereke is the only one who actually gets up and goes around. The other members just sit around while Okereke goes off on his own journey, whilst cigarette burn effects and other visual distortions appear.
The song was featured in the racing video game Project Gotham Racing 4 (also required for the Tonight Make Me Unstoppable achievement, which requires you to finish a race in second place with this song playing.), while the Does It Offend You, Yeah? remix was featured on Need for Speed: ProStreet. The song was also featured in the general trailer of the sixth season of Smallville in March and April 2007. The song was also featured in the soundtrack for the video game NHL 2K8.