The Presbytère, originally called the Casa Curial (Ecclesiastical House), derives its name from the fact that it was built on the former site of the residence, or presbytére, of the Capuchin monks. While intended to house clergy, it was never used as a religious residence. It was designed in 1791 to match the the Cabildo, or Town Hall, on the other side of St. Louis Cathedral. The second floor, however, was not completed until 1813.
The building initially was used for commercial purposes until 1834, when it was used by the Louisiana Supreme Court. In 1847 the structure's third floor with mansard roof was added.
In 1853, cathedral officials sold the Presbytère to the city, and in 1908 the city sold it to the state. In 1911 it became part of the Louisiana State Museum.