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Structural formula of thiocarlide
Space-filling model of the thiocarlide molecule
Systematic (IUPAC) name
CAS Registry Number 910-86-1 N
ATC code J04AD02
PubChem CID: 3001386
ChemSpider 2272774 YesY
UNII 43M23X81Y2 YesY
Chemical data
Formula C23H32N2O2S
Molecular mass 400.578 g/mol
 N (what is this?)  (verify)

Thiocarlide (or tiocarlide or isoxyl) is a thiourea drug used in the treatment of tuberculosis, inhibiting synthesis of oleic acid and tuberculostearic acid.[1]

Thiocarlide has considerable antimycobacterial activity in vitro and is effective against multi-drug resistant strains of Mycobacterium tuberculosis.[2] Isoxyl inhibits M. bovis with six hours of exposure, which is similar to isoniazid and ethionamide, two other prominent anti-TB drugs. Unlike these two drugs, however, isoxyl also partially inhibits the synthesis of fatty acids.

Thiocarlide was developed by a Belgian company, Continental Pharma S.A. Belgo-Canadienne in Brussels, Belgium. The head researcher was Professor N. P. Buu-Hoi, head of Continental Pharma's Research Division.


  1. ^ Phetsuksiri B, Jackson M, Scherman H et al. (December 2003). "Unique mechanism of action of the thiourea drug isoxyl on Mycobacterium tuberculosis". J. Biol. Chem. 278 (52): 53123–30. doi:10.1074/jbc.M311209200. PMID 14559907. 
  2. ^ Phetsuksiri B, Baulard AR, Cooper AM et al. (May 1999). "Antimycobacterial activities of isoxyl and new derivatives through the inhibition of mycolic acid synthesis". Antimicrob. Agents Chemother. 43 (5): 1042–51. PMC 89109. PMID 10223912.