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Thioescaline (TE) is a pair of lesser-known psychedelic drugs with the chemical formula C12H19NO2S. They structural analogs of escaline in which an oxygen atom has been replaced with a sulfur atom. They were first synthesized by Alexander Shulgin and reported in his book PiHKAL.[1][2] Very little is known about their dangers or toxicity.


3-TE, or 3-methylthio-4-ethoxy-5-methoxyphenethylamine

Dosage: 60–80 mg

Duration: 8–12 hours

Effects: increased pleasure from art and music, lowering of pitch, and time distortion


4-TE, or 4-ethylthio-3,5-dimethoxy-phenethylamine

Dosage: 20–30 mg

Duration: 9–12 hours

Effects: open-eye visuals, easy conversation. +++ on the Shulgin Rating Scale

See also[edit]