Thioperamide

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Thioperamide
Thioperamide.svg
Clinical data
ATC code
  • none
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
Chemical and physical data
Formula C15H24N4S
Molar mass 292.44 g/mol
3D model (JSmol)
 NYesY (what is this?)  (verify)

Thioperamide is a potent HRH4 antagonist and selective HRH3 antagonist capable of crossing the blood–brain barrier.[1] It was used by Jean-Charles Schwartz in his early experiments regarding the H3 receptor.[2] Thioperamide was found to be an antagonist of histamine autoreceptors, which negatively regulate the release of histamine, and enhances the activity of histaminergic neurons by blocking autoreceptors, leading to greater release of histamine.

Its action on H3 is thought to promote wakefulness and improve memory consolidation.

See also[edit]

References[edit]

  1. ^ "IUPHAR Database | Ligand Summary | thioperamide". 
  2. ^ Schwartz, Jean-Charles. The histamine H3 receptor: from discovery to clinical trials with pitolisant. BPJ 2011 May [1]