Thiosulfate—thiol sulfurtransferase

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thiosulfate-thiol sulfurtransferase
EC number
CAS number 111070-24-7
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a thiosulfate-thiol sulfurtransferase (EC is an enzyme that catalyzes the chemical reaction

thiosulfate + 2 glutathione sulfite + glutathione disulfide + sulfide

Thus, the two substrates of this enzyme are thiosulfate and glutathione, whereas its 3 products are sulfite, glutathione disulfide, and sulfide.

This enzyme belongs to the family of transferases, specifically the sulfurtransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is thiosulfate:thiol sulfurtransferase. Other names in common use include glutathione-dependent thiosulfate reductase, sulfane reductase, and sulfane sulfurtransferase. This enzyme participates in glutathione metabolism.


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  • Sido B; Koj A (1972). "Separation of rhodanese and thiosulfate reductase activities in carp liver extracts". Acta Biol. Cracow Ser. Zoo. 15: 97–103. 
  • Uhteg LC, Westley J (1979). "Purification and steady-state kinetic analysis of yeast thiosulfate reductase". Arch. Biochem. Biophys. 195 (1): 211–22. doi:10.1016/0003-9861(79)90343-6. PMID 383018.