Anantharaman obtained a B.Tech. degree in Electronics in 1982 from the Institute of Technology, Banaras Hindu University (now Indian Institute of Technology (BHU) Varanasi). He got (in 1977) IIT-JEE rank (AIR) # 2. Anantharaman went to USA and joined Carnegie Mellon University as a PhD student where he worked on the chess playing computers ChipTest and DeepThought with Feng-hsiung Hsu. Anantharaman received his PhD degree in 1990 and joined the field of biotechnology and Feng-hsiung Hsu joined IBM to design the Deep Blue IBM super-computer, which defeated Garry Kasparov in the historic chess match.
In 1985, Carnegie Mellon University graduate students Feng-hsiung Hsu, Anantharaman, Murray Campbell and Andreas Nowatzyk used spare chips they'd found to put together a chess-playing machine that they called ChipTest. By 1987, the machine, integrating some innovative ideas about search strategies, had become the reigning computer chess champion. A successor, Deep Thought, using two special-purpose chips, plus about 200 off-the-shelf chips, working in parallel, achieved grandmaster-level play.
Following this work, Anantharaman focused his attentions into the field of biostatistics and the application of Bayesian methods to the analysis of single molecule Optical Mapping technologies. Currently he is working as Senior Bioinformatics Software Engineer at Opgen, Inc, Madison, Wisconsin.
Nicole T. Perna, Guy Plunkett III, Valerie Burland, Bob Mau, Jeremy D. Glasner, Debra J. Rose, George F. Mayhew, Peter S. Evans, Jason Gregor, Heather A. Kirkpatrick, György Pósfai, Jeremiah Hackett, Sara Klink, Adam Boutin, Ying Shao, Leslie Miller, Erik J. Grotbeck, N. Wayne Davis, Alex Lim, Eileen T. Dimalanta, Konstantinos D. Potamousis, Jennifer Apodaca, Thomas S. Anantharaman, Jieyi Lin, Galex Yen, David C. Schwartz, Rodney A. Welch and Frederick R. Blattner (2001). "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7". Nature409 (6819): 529–533. doi:10.1038/35054089. PMID11206551.