Thymoquinone

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Thymoquinone
Thymoquinone.png
Names
IUPAC name
2-Isopropyl-5-methylbenzo-1,4-quinone
Other names
Thymoquinone
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.007.020
Properties
C10H12O2
Molar mass 164.20 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Thymoquinone is a phytochemical compound found in the plant Nigella sativa. It is also found in select cultivated Monarda fistulosa plants grown and steam distilled in the USA producing an essential oil.

In laboratory experiments in cells and in animals, it has shown anti-inflammatory and anti-oxidant effects, and has been studied in models of cardiovascular diseases and diabetes,[1] neurodegenerative diseases and stroke,[2] and cancer.[3]

It has been classified as a pan-assay interference compound, which binds indiscriminately to many proteins.[4]

See also[edit]

References[edit]

  1. ^ Farkhondeh, T; Samarghandian, S; Borji, A (September 2017). "An overview on cardioprotective and anti-diabetic effects of thymoquinone". Asian Pacific journal of tropical medicine. 10 (9): 849–854. doi:10.1016/j.apjtm.2017.08.020. PMID 29080612. 
  2. ^ Khazdair, Mohammad Reza (2015-01-01). "The Protective Effects of Nigella sativa and Its Constituents on Induced Neurotoxicity". Journal of Toxicology. 2015: 841823. doi:10.1155/2015/841823. ISSN 1687-8191. PMC 4641935Freely accessible. PMID 26604923. 
  3. ^ Khan, MA; Tania, M; Fu, S; Fu J (Apr 18, 2017). "Thymoquinone, as an anticancer molecule: from basic research to clinical investigation". Oncotarget. 8 (31): 51907–51919. doi:10.18632/oncotarget.17206. PMC 5584300Freely accessible. PMID 28881699. 
  4. ^ Baell, JB (25 March 2016). "Feeling Nature's PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS)". Journal of Natural Products. 79 (3): 616–28. doi:10.1021/acs.jnatprod.5b00947. PMID 26900761.